(Legend)

Generic Name

• Loxapine
  T½ = 5 h/12–19 h
  Pregnancy category C

Trade Name

• Loxitane
• Loxapac;Adasuve Inhalant

Dose Range/Adult Daily Dose

• Range: 20–250 mg/d
  Start: 10 mg po 2 × daily, ↑ until psychotic symptom improvement. Acute agitation in Bipolar I or schizophrenia patient: 10 mg in a single-use inhaler. Only 1 dose in 24 h. Only administered by “enrolled health care facilities.”

Use/Common Side Effects (CSE)

• Use: Schizophrenia (second line Rx); Adasuve Inhalant: Acute agitation in Bipolar I and schizophrenic adults. Off label: Other psychotic disorders, bipolar.
  CSE: Drowsiness, orthostatic hypotension, ataxia, constipation, nausea, blurred vision. Adasuve Inhalation: CSE: Unpleasant taste, sedation, throat irritation; Black box warning: BRONCHOSPASM. Screen for contraindications: asthma, COPD, wheezing.

Geriatric & Dose Considerations

• Evaluate/monitor for confusion, orthostatic hypotension, sedation, ↓ dose; at risk for falls; ↑mortality in elderly with dementia-related psychosis

Classification

• Antipsychotic [Conventional]

Assessment Cautions

• Contraindicated: Severe CNS depression/coma.
  Caution: Parkinson's, bone marrow suppression, cardiac, renal, respiratory disease; sedating, Monitor for EPS, NMS, TD, BMI, FBS, lipids