(Legend)

Generic Name

• Clomipramine
  T½ = 20–30 h
  Pregnancy category C

Trade Name

• Anafranil
• Apo-Clomipramine

Dose Range/Adult Daily Dose

• Range: 25–250 mg/d po
  Start 25 mg/d po; gradually increase to 100 mg/d (up to 250 mg/d)

Use/Common Side Effects (CSE)

• Use: OCD
  CSE: Dizziness, drowsiness, increased appetite, weight gain, constipation, nausea

Geriatric & Dose Considerations

• Use with caution in elderly (sedation, orthostatic hypotension; CV disease; BPH)

Classification

• Antidepressant [TCA]

Assessment Cautions

• Caution: CV disease including conduction abnormalities, hx: seizures, bipolar, hypotensive disorders; avoid alcohol; fatal with MAOIs.