(Legend)

Generic Name

• Desipramine
  T½ = 12–27 h
  Protein binding = 90%–92%
  Pregnancy category C

Trade Name

• Norpramin
• Pertofrane

Dose Range/Adult Daily Dose

• Range: 25–300 mg/d 100–200 mg/d po single or divided doses (up to 300 mg/d)

Use/Common Side Effects (CSE)

• Use: Depression; unlabeled: chronic pain
  CSE: Blurred vision, dry eyes, dry mouth, sedation, hypotension, constipation ARRHYTHMIAS

Geriatric & Dose Considerations

• Reduce dosage: 25–50 mg/d po (in divided doses (up to 150 mg/d); sedation. Caution with CV disease, BPH; monitor BP & pulse

Classification

• Antidepressant [TCA]

Assessment Cautions

• Contraindicated: Narrow-angle glaucoma. Monitor BP/pulse; ECG prior to and through Rx if hx of CV disease or high doses