(Legend)

Generic Name

• Pimozide
  T½ = 29–111 h
  Protein binding = 99%
  Pregnancy category C

Trade Name

• Orap

Dose Range/Adult Daily Dose

• Range: 2–10 mg/d
  Start 1–2 mg/d po, increase as needed every other day

Use/Common Side Effects (CSE)

• Use: Tourette's, psychosis (2^nd line Rx)
  CSE: Orthostatic hypotension, palpitations, QT prolongation, drowsiness, dizziness, blurred vision

Geriatric & Dose Considerations

• Moderately sedating; caution in Parkinson's, arrhythmias, cerebrovascular, cardiovascular disease; may cause orthostatic hypotension; ↑mortality in elderly with dementia-related psychosis

Classification

• Antipsychotic [Conventional]

Assessment Cautions

• Contraindicated: CNS depression, prolonged QT syndrome, dysrhythmias. Caution in respiratory, CV, hepatic, renal disease. Assess for EPS, TD, akathisia, NMS, BMI, FBS, and lipids.