(Legend)

Generic Name

• Doxepin
  T½ = 8–25 h
  Pregnancy category C

Trade Name

• Sinequan
• Zonalon
• Triadapin

Dose Range/Adult Daily Dose

• Range: 25–300 mg/d po 25 mg po 3 × daily, up to 150 mg (inpatient up to 300 mg/d)

Use/Common Side Effects (CSE)

• Use: Depression/anxiety
  CSE: Blurred vision, dry eyes, dry mouth, sedation, hypotension, constipation, ARRHYTHMIAS

Geriatric & Dose Considerations

• Dose reduction: 25–50 mg/d po initially, increase as needed; Caution with preexisting CV disease, BPH; assess for falls and anticholinergic effects

Classification

• Antidepressant [TCA]

Assessment Cautions

• Monitor blood pressure and pulse; ECGs with hx of CV disease; WBC w diff, LFTs, and serum glucose periodically