(Legend)

Generic Name

• Sertraline
  T½ = 24 h
  Protein binding = 98%
  Pregnancy category C

Trade Name

• Zoloft

Dose Range/Adult Daily Dose

• Range: 50–200 mg/d
  Depression/OCD: Start: 50 mg/d po AM or PM, may ↑ slowly/weekly to 200 mg/d
  Panic disorder: Start: 25 mg/d po, up to 50 mg/d
  PTSD/SAD: Start: 25 mg/d po (to 200 mg/d)

Use/Common Side Effects (CSE)

• Use: Depression, panic disorder, OCD, PTSD, social anxiety disorder (SAD), PMDD; Off label: GAD
  CSE: Drowsiness, dizziness, headache, fatigue, insomnia, nausea, diarrhea, dry mouth, sexual dysfunction, sweating, tremor

Geriatric & Dose Considerations

• Caution with drowsiness, hepatic/renal impairment; start with lower dose.

Classification

• Antidepressant [SSRI]

Assessment Cautions

• Contraindicated: Concurrent Pimozide or MAOIs (serious fatal reactions), need 14 d washout period. Do not use with St. John's wort or SAMe. Caution: Hepatic/renal/pregnancy/lactation/seizures/hx mania. Peds/Adol: May increase the risk of suicidal thinking and behavior and must be closely monitored.