(Legend)

Generic Name

• Gabapentin
  T½ = 5–7 h
  Pregnancy category C

Trade Name

• Neurontin
• Gabarone

Dose Range/Adult Daily Dose

• Range: 900–1800 mg/d
  Start: 300 mg po 3 × daily; titrate up to 1800 mg/d in divided doses (doses up to 3600 mg/d have been used)

Use/Common Side Effects (CSE)

• Use: Partial seizures. Off label: Bipolar disorder and chronic pain
  CSE: Drowsiness, ataxia, confusion, depression; may also cause dizziness, hostility, vertigo, hypertension, anorexia

Geriatric & Dose Considerations

• Use cautiously; especially with renal impairment (↓ dose and/or ↑ dosing interval).

Classification

• Anticonvulsant/mood stabilizer

Assessment Cautions

• Caution: Renal impairment (↓ dose). Discontinuation requires at least 1 wk; should be done gradually; dosages no more than 12 h apart. Risk of CNS depression with alcohol, opioids, other CNS depressants.