(Legend)

Generic Name

• Imipramine
  T½ = 8–16 h
  Protein binding = 89–95%
  Pregnancy category C

Trade Name

• Tofranil
• Impril

Dose Range/Adult Daily Dose

• Range: 30–300 mg/d 25–50 mg po 3–4 × daily (not to exceed 300 mg/d)

Use/Common Side Effects (CSE)

• Use: Depression
  CSE: Blurred vision, dry eyes, dry mouth, sedation, constipation, hypotension, ARRHYTHMIAS

Geriatric & Dose Considerations

• 25 mg po hs initially, up to 100 mg/d, divided doses; Use cautiously in elderly, preexisting CV disease (monitor ECGs), BPH

Classification

• Antidepressant [TCA]

Assessment Cautions

• Monitor ECGs in heart disease; also BP and pulse.
  Contraindicated: Concurrent MAOIs; avoid use with SSRIs, or clonidine