(Legend)

Generic Name

• Lamotrigine
  T½ = 25.4 h (on lamotrigine alone)
  Pregnancy category C

Trade Name

• Lamictal

Dose Range/Adult Daily Dose

• Range: 75–250 mg/d
  Bipolar pt not on CBZ/VA: Start 25 mg/d po × 2 wk, then 50 mg/d × 2 wk, then 100 mg/d × 1 wk, then 200 mg/d

Use/Common Side Effects (CSE)

• Use: Partial seizures, bipolar I disorder maintenance
  CSE: Nausea, vomiting, dizziness, headache, ataxia photosensitivity, rash, STEVENS-JOHNSON SYNDROME (SJS), ARRHYTHMIAS (3/2021)

Geriatric & Dose Considerations

• May cause dizziness/drowsiness; Caution with impaired renal/CV/hepatic disease

Classification

• Anticonvulsant/mood stabilizer

Assessment Cautions

• Contrainidicated: Lactation. Caution: Impaired renal/cardiac/hepatic function, hx rash on lamotrigine. Avoid abrupt discontinuation. Assess for skin rash. Sx of SJS: Cough, FUO, mucosal lesions, rash; stop lamotrigine