The GITSG 9273 trial (pts enrolled in the 1970s). Arm 1: RT alone, split-course 60 Gy in 2 Gy/fx; arm 2: 5-FU + RT, split-course RT to 40 Gy in 2 Gy/fx; arm 3: 5-FU + RT, split-course RT to 60 Gy in 2 Gy/fx. All arms rcvd maintenance 5-FU × 2 yrs. MS favored the CRT arms: 5.3 mos (arm 1) vs. 9.7 mos (arm 2) vs. 9.3 mos (arm 3). 1-yr OS favored the CRT arms: 10% (arm 1) vs. 35% (arm 2) vs. 46% (arm 3). There were no statistical differences b/t the CRT arms. (MoertelCG et al., Cancer 1981)