ECOG 4201, which closed early d/t slow accrual. 74 pts (71 evaluable). Arm 1: gemcitabine alone; arm 2: gemcitabine + RT, then gemcitabine alone. MS and 2-yr OS were better with CRT (11.1 mos vs. 9.2 mos and 12% vs. 4%, respectively). There were higher G4/5 toxicities with arm 2, but G3/4 toxicities were similar. (LoehrerPJ et al., JCO 2011)