Yes. Tx paradigms can differ b/t pancreatic vs. periampullary cancers. Consider observation for completely resected T1-T2, N0 ampulla of Vater carcinoma. Retrospective reviews suggest high OS (5-yr OS ∼80%) with observation alone (WillettC et al., Surg Gynecol Obstet 1993). Otherwise, periampullary adenocarcinoma generally follows PCA paradigms, especially for T3-T4, poor histologic grade, LVSI/PNI (KrishnanS et al., IJROBP 2008), or node+ pts. (ZhouJ et al., Radiother Oncol 2009)