Authored by Steven Eric Finkelstein and John P. Christodouleas

1. What are the key functions of the innate immune system?  

2. What are the key functions of the adaptive immune system?  

3. How does the adaptive immune response provide long-lasting protection?  

4. How does cancer evade the immune system?  

5. Name 4 major types of immunotherapy.  

6. How do checkpoint inhibitors work?  

7. What type of cancers are most successfully treated with checkpoint inhibitor immunotherapy?  

8. What are the side effects of checkpoint inhibitors and how are they managed?  

9. Is dual agent checkpoint inhibition more effective than single agent?  

10. How does adoptive cell transfer work?  

11. What is CAR T-cell therapy?  

12. Describe the ELIANA trial which resulted in the 1^st FDA approval of a CAR T-cell therapy.  

13. How does sipuleucel-T works?  

14. What evidence supports the benefit of sipuleucel-T?  

15. What is the abscopal effect?  

16. Is there evidence to support the use of RT to improve the rate and durability of the systemic response of checkpoint inhibitors in metastatic Dz?  

17. How may RT promote immune-mediated killing of an irradiated tumor?