There is no standard neoadj Tx for PCA. Use similar paradigms as for locally advanced cases: multi-agent chemo for at least 4 cycles f/b consideration of fluoropyrimidine-based CRT, e.g., (1) gemcitabine/Abraxane or FOLFIRINOX (leucovorin, fluorouracil, irinotecan, and oxaliplatin) +/− fluoropyrimidine-based chemo/RT, with RT to 45-50.4 Gy in 1.8-2 Gy/fx or 30 Gy in 3 Gy/fx per the MDACC paradigm. (BreslinTM et al., Ann Surg Oncol 2001)