Locally advanced unresectable PCA Tx paradigm: biliary stent (if jaundice) can be done 1^st then based on KPS→ (1) induction chemo → restage → CRT, (2) definitive CRT if not candidate for multi-agent chemo, or (3) chemo alone. CRT regimens typically involve 5-FU or gemcitabine. Chemo alone or induction chemo involves gemcitabine (poor KPS or unable to tolerate multiple agents), gemcitabine + Abraxane, FOLFIRINOX, or other combination in clinical study. Multi-agent chemo is preferred, and 4-6 cycles for induction chemo.