Absorption: Well absorbed after oral administration.
Distribution: Widely distributed. Enters breast milk in small amounts; probably crosses the placenta.
Protein Binding: 92%.
Metabolism/Excretion: Mostly metabolized by the liver (CYP2D6 isoenzyme);the CYP2D6 enzyme system exhibits genetic polymorphism; 7% of population may be poor metabolizers (PMs) and may have significantly ↑ nortriptyline concentrations and an ↑ risk of adverse effects.
Half-life: 1828 hr.
Contraindicated in:
Use Cautiously in:
CV: ARRHYTHMIAS, hypotension, ECG changes.
Derm: photosensitivity.
EENT: blurred vision, dry eyes, dry mouth.
Endo: gynecomastia.
GI: constipation, nausea, paralytic ileus, unpleasant taste, weight gain.
GU: urinary retention.
Hemat: blood dyscrasias.
Neuro: SUICIDAL THOUGHTS, drowsiness, fatigue, lethargy, agitation, confusion, extrapyramidal reactions, hallucinations, headache, insomnia.
Drug-Drug:
Drug-Natural Products:
(Generic available)
NDC Code*