section name header

Pronunciation ⬇

nor-TRIP-ti-leen audio

Indications ⬆ ⬇

BEERS REMS

Unlabeled Use:

Action ⬆ ⬇

Therapeutic Effects:

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed. Enters breast milk in small amounts; probably crosses the placenta.

Protein Binding: 92%.

Metabolism/Excretion: Mostly metabolized by the liver (CYP2D6 isoenzyme);the CYP2D6 enzyme system exhibits genetic polymorphism; 7% of population may be poor metabolizers (PMs) and may have significantly ↑ nortriptyline concentrations and an ↑ risk of adverse effects.

Half-life: 18–28 hr.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: ARRHYTHMIAS, hypotension, ECG changes.

Derm: photosensitivity.

EENT: blurred vision, dry eyes, dry mouth.

Endo: gynecomastia.

GI: constipation, nausea, paralytic ileus, unpleasant taste, weight gain.

GU: urinary retention.

Hemat: blood dyscrasias.

Neuro: SUICIDAL THOUGHTS, drowsiness, fatigue, lethargy, agitation, confusion, extrapyramidal reactions, hallucinations, headache, insomnia.

Interactions ⬆ ⬇

Drug-Drug:

Drug-Natural Products:

Route/Dosage ⬆ ⬇

Implementation ⬆ ⬇

US Brand Names ⬆ ⬇

Pamelor

Canadian Brand Names ⬆ ⬇

Aventyl

Classifications ⬆ ⬇

Therapeutic Classification: antidepressants

Pharmacologic Classification: tricyclic antidepressants

Availability ⬆ ⬇

(Generic available)

Time/Action Profile ⬆ ⬇

(antidepressant effect)

ROUTEONSETPEAKDURATION
PO2–3 wk6 wkunknown

Assessment ⬆ ⬇

Lab Test Considerations: Toxicity and Overdose:

Pot. Nursing Diagnoses ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

Code ⬆

NDC Code*