Absorption: Rapidly absorbed; bioavailability unknown.
Distribution: Well distributed; moderately (60%) bound to plasma proteins.
Metabolism/Excretion: Highly (90%) metabolized by the liver; <10% eliminated unchanged.
Half-life: 15 hr.
Contraindicated in:
Use Cautiously in:
CV: arrhythmias, chest pain, hypertension, hypotension, syncope, vasodilation.
Derm: STEVENS-JOHNSON SYNDROME, dry skin, herpes simplex, rash.
EENT: rhinitis, abnormal vision, amblyopia, epistaxis, pharyngitis.
Endo: hyperglycemia.
GI: ↑liver enzymes, nausea, anorexia, diarrhea, gingivitis, mouth ulcers, thirst, vomiting.
GU: abnormal ejaculation, albuminuria, urinary retention.
Hemat: eosinophilia.
MS: joint disorder, neck pain.
Neuro: ataxia, dyskinesia, hypertonia, paresthesia, tremor , SUICIDAL IDEATION, headache, aggression, amnesia, anxiety, cataplexy, confusion, delusions, depression, dizziness, hallucinations, insomnia, mania, nervousness, seizures.
Resp: dyspnea, lung disorder.
Misc: infection.
Drug-Drug:
Drug-Natural Products:
Hepatic Impairment
NDC Code*