sye-kloe-BEN-za-preen 
Unlabeled Use:
Absorption: Well absorbed from the GI tract.
Distribution: Unknown.
Protein Binding: 93%.
Metabolism/Excretion: Mostly metabolized by the liver.
Half-life: 1–3 days.
Contraindicated in:
Use Cautiously in:
CV: arrhythmias.
EENT: dry mouth, blurred vision.
GI: constipation, dyspepsia, nausea, unpleasant taste.
GU: urinary retention.
Neuro: dizziness, drowsiness, confusion, fatigue, headache, nervousness.
Drug-Drug:
Drug-Natural Products:
15 yo): Acute painful musculoskeletal conditions — Immediate-release: 10 mg 3 times daily (range 20–40 mg/day in 2–4 divided doses; not to exceed 60 mg/day); Extended-release: 15–30 mg once daily. Fibromyalgia — 5–40 mg at bedtime (unlabeled).Amrix, Flexeril
(Generic available)
(skeletal muscle relaxation)
| ROUTE | ONSET | PEAK† | DURATION |
|---|---|---|---|
| PO | within 1 hr | 3–8 hr | 12–24 hr |
| Extended release | unknown | unknown | 24 hr |
NDC Code*