PROE-poe-fol 
Absorption: Administered IV only, resulting in complete absorption.
Distribution: Rapidly and widely distributed. Crosses the blood-brain barrier well; rapidly redistributed to other tissues. Crosses the placenta and enters breast milk.
Protein Binding: 95–99%.
Metabolism/Excretion: Rapidly metabolized by the liver.
Half-life: 3–12 hr (blood-brain equilibration half-life 2.9 min).
Contraindicated in:
Use Cautiously in:
Neuro: dizziness, headache.
Resp: apnea, cough.
CV: bradycardia, hypotension, hypertension.
GI: abdominal cramping, hiccups, nausea, vomiting.
Derm: flushing.
Local: burning, pain, stinging, coldness, numbness, tingling at IV site.
MS: involuntary muscle movements, perioperative myoclonia.
GU: discoloration of urine (green).
Misc: PROPOFOL INFUSION SYNDROME, fever.
Drug-Drug:
General Anesthesia
3 yr–16 yr): Induction — 2.5–3.5 mg/kg, use lower dose for children ASA III or IV.Monitored Anesthesia Care (MAC) Sedation
ICU Sedation
IV Administration:
2 mg/mL.
(loss of consciousness)
| ROUTE | ONSET | PEAK | DURATION† |
|---|---|---|---|
| IV | 40 sec | unknown | 3–5 min |
†Time to recovery is 8 min (up to 19 min if opioid analgesics have been used).
60 sec. Maintain patent airway and adequate ventilation. Propofol should be used only by individuals experienced in endotracheal intubation, and equipment for this procedure should be readily available.NDC Code*