ZOLE-pi-dem 
Absorption: Rapidly absorbed following oral administration. Controlled-release formulation releases 10 mg immediately, then another 2.5 mg later.
Distribution: Minimal amounts enter breast milk; remainder of distribution not known.
Metabolism/Excretion: Converted to inactive metabolites, which are excreted by the kidneys; clearance of Intermezzo lower in women than in men.
Half-life: 2.5–3 hr (↑ in geriatric patients and patients with hepatic impairment).
Contraindicated in:
Use Cautiously in:
EENT: blurred vision, double vision.
GI: diarrhea, nausea, vomiting.
Neuro: COMPLEX SLEEP BEHAVIORS (INCLUDING SLEEP DRIVING, SLEEP WALKING, OR ENGAGING IN OTHER ACTIVITIES WHILE SLEEPING), daytime drowsiness, dizziness, abnormal thinking, agitation, amnesia, behavior changes, hallucinations, prolonged reaction time.
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), physical dependence, psychological dependence, tolerance.
Drug-Drug:
Drug-Natural Products:
Drug-Food:
Ambien, Ambien CR, Edluar, Intermezzo, Zolpimist
(Generic available)
(sedation)
| ROUTE | ONSET | PEAK* | DURATION |
|---|---|---|---|
| PO | rapid | 30 min–2 hr | 6–8 hr |
| PO-ER | rapid | 2–4 hr | 6–8 hr |
| PO-Spray | rapid | unknown | unknown |
| SL | rapid | unknown | unknown |
NDC Code*
