loe-PER-a-mide 
Absorption: Not well absorbed following oral administration.
Distribution: Unknown. Does not cross the blood-brain barrier.
Protein Binding: 97%.
Metabolism/Excretion: Metabolized partially by the liver, undergoes enterohepatic recirculation; 30% eliminated in the feces. Minimal excretion in the urine.
Half-life: 10.8 hr.
Contraindicated in:
Use Cautiously in:
CV: CARDIAC ARREST, QT INTERVAL PROLONGATION, TORSADES DE POINTES, VENTRICULAR ARRHYTHMIAS, syncope.
GI: constipation, abdominal pain/distention/discomfort, dry mouth, nausea, vomiting.
Neuro: drowsiness, dizziness.
Misc: allergic reactions.
Drug-Drug:
Drug-Natural Products:
Acute and Chronic Diarrhea
Acute Diarrhea
Chronic Diarrhea
(Generic available)
NDC Code*