te-NOE-fo-veer dye-soe-PROX-il FUE-ma-rate 
Absorption: Tenofovir disoproxil fumarate is a prodrug, which is split into tenofovir, the active component. Absorption enhanced by food.
Distribution: Minimally distributed to extravascular tissues.
Metabolism/Excretion: 70–80% excreted unchanged in urine by glomerular filtration and active tubular secretion.
Half-life: Unknown.
Contraindicated in:
Use Cautiously in:
Derm: rash.
F and E: hypophosphatemia.
GI: LACTIC ACIDOSIS/HEPATOMEGALY WITH STEATOSIS, diarrhea, nausea, abdominal pain, anorexia, vomiting, flatulence.
GU: ACUTE RENAL FAILURE/FANCONI SYNDROME, proximal renal tubulopathy, renal impairment.
MS: bone pain, ↓ bone mineral density, muscle pain, osteomalacia.
Neuro: depression, headache, weakness.
Misc: immune reconstitution syndrome.
Drug-Drug:
2 yr and 35 kg): 300 mg once daily.2 yr and 17–34.9 kg): Tablets:28–34.9 kg — 250 mg once daily; 22–27.9 kg — 200 mg once daily; 17–21.9 kg — 150 mg once daily.2 yr and 10–34.9 kg): Oral Powder:34–34.9 kg — 7 scoops (280 mg) once daily; 32–33.9 kg — 6.5 scoops (260 mg) once daily; 29–31.9 kg — 6 scoops (240 mg) once daily; 27–28.9 kg — 5.5 scoops (220 mg) once daily; 24–26.9 kg — 5 scoops (200 mg) once daily; 22–23.9 kg — 4.5 scoops (180 mg) once daily; 19–21.9 kg — 4 scoops (160 mg) once daily; 17–18.9 kg — 3.5 scoops (140 mg) once daily; 14–16.9 kg — 3 scoops (120 mg) once daily; 12–13.9 kg — 2.5 scoops (100 mg) once daily; 10–11.9 kg — 2 scoops (80 mg) once daily.Renal Impairment
Therapeutic Classification: antiretrovirals
Pharmacologic Classification: nucleoside reverse transcriptase inhibitors
(Generic available)
NDC Code*