proe-klor-PAIR-a-zeen 
Absorption: Absorption from tablet is variable; may be better with oral liquid formulations. Well absorbed after IM administration.
Distribution: Widely distributed, high concentrations in the CNS. Crosses the placenta and probably enters breast milk.
Protein Binding: 
90%.
Metabolism/Excretion: Highly metabolized by the liver and GI mucosa. Converted to some compounds with antipsychotic activity.
Half-life: Unknown.
Contraindicated in:
Use Cautiously in:
EENT: blurred vision, dry eyes, lens opacities.
CV: ECG changes, hypotension, tachycardia.
GI: constipation, dry mouth, anorexia, drug-induced hepatitis, ileus.
GU: pink or reddish-brown discoloration of urine, urinary retention.
Derm: photosensitivity, pigment changes, rashes.
Endo: galactorrhea.
Hemat: AGRANULOCYTOSIS, leukopenia.
Metab: hyperthermia.
Neuro: NEUROLEPTIC MALIGNANT SYNDROME, extrapyramidal reactions, sedation, tardive dyskinesia.
Misc: allergic reactions.
Drug-Drug:
Drug-Natural Products:
Antiemetic
12 yr): 5–10 mg 3–4 times daily (not to exceed 40 mg/day).12 yr): 5–10 mg every 3–4 hr as needed. Nausea/vomiting associated with surgery — 5–10 mg; may be repeated once.12 yr): 2.5–10 mg (not to exceed 40 mg/day). Nausea/vomiting associated with surgery — 5–10 mg; may be repeated once.Antipsychotic
12 yr): 5–10 mg 3–4 times daily; may be ↑ every 2–3 days (up to 150 mg/day).12 yr): 2.5–10 mg (up to 40 mg/day).Antianxiety
12 yr): 5 mg 3–4 times daily (not to exceed 20 mg/day or longer than 12 wk).12 yr): 5–10 mg every 3–4 hr as needed (up to 40 mg/day).IV Administration:
Compazine, Compro
(Generic available)
(antiemetic effect)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | 30–40 min | unknown | 3–4 hr |
| Rect | 60 min | unknown | 3–4 hr |
| IM | 10–20 min | 10–30 min | 3–4 hr |
| IV | rapid (min) | 10–30 min | 3–4 hr |
NDC Code*