a-DAP-a-leen

• Management of acne vulgaris.

• Binds to retinoic acid nuclear receptors resulting in decreased microcomedone formation.

• Reduction in inflammatory and non-inflammatory acne lesions.

Absorption: Minimal systemic absorption occurs with limited surface-area application.

Distribution: Unknown.

Metabolism/Excretion: Excreted via the biliary route.

Half-life: Unknown.

Contraindicated in:

• Hypersensitivity.

Use Cautiously in:

• OB: Use during pregnancy only if potential benefit justifies the potential risk to the fetus
• Lactation: Safety not established
• Pedi: Children <12 yr (safety and effectiveness not established).

Derm: burning, dryness, erythema, pruritus, scaling, photosensitivity.

Drug-Drug:

• Concurrent use with keratolytic agents (benzoyl peroxide, salicylic acid, sulfur, or resorcinol) ↑ risk of excessive skin irritation.
• ↑risk of photosensitivity with other photosensitizing agents.
• Risk of irritation ↑ by other topical skin-care products (aftershave, cover-up, make-up, perfumes, colognes).

• Topical (Adults and Children 12 yr): Apply once daily at bedtime.

• Topical: Cleanse area with mild or soapless cleanser before applying medication. Apply thin film of cream to areas where acne lesions appear, once daily at nighttime. A mild transitory sensation of warmth or slight stinging may occur shortly after application. Avoid contact with the eyes, lips, angles of the nose, and mucous membranes. Do not apply to cuts, abrasions, eczematous or sunburned skin. May use moisturizers but avoid products containing alpha hydroxy or glycolic acid. Avoid waxing skin in treated area.

Differin

Therapeutic Classification: antiacne agents

Pharmacologic Classification: retinoids

(Generic available)

• Cream: 0.1%;
• Gel: 0.3% ^OTC;
• Lotion: 0.1%;

(improved skin appearance)

• Assess skin prior to and periodically during therapy. Transient worsening of acne may occur at initiation of therapy. Note degree of skin dryness, erythema, and itching. Usually occur during first 2–4 wks of therapy. May need to reduce frequency or discontinue therapy.

• Risk for impaired skin integrity (Indications, Side Effects).
• Disturbed body image (Indications).

• Instruct patient on correct technique for application of cream.
• Explain to patient that a temporary worsening of acne may occur at beginning of therapy.
• Caution patient to use sunscreen and protective clothing to prevent photosensitivity reactions. Health care professional should be consulted about sunscreen, as some sunscreens may worsen acne.
• Advise female patients to notify health care professional if pregnancy is planned or suspected or if breast feeding.

• Reduction in inflammatory and non-inflammatory acne lesions.

NDC Code^*

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-6301- Adapalene
    • 0093-6301-95- 45 g in 1 TUBE (0093-6301-95)

• 0168- E. Fougera and Co. a division of Fougera Pharmaceuticals Inc.
  • 0168-0424- Adapalene
    • 0168-0424-46- 1 TUBE in 1 CARTON (0168-0424-46) > 45 g in 1 TUBE

• 0299- Galderma Laboratories, L.P.
  • 0299-4910- Differin
    • 0299-4910-00- 1 TUBE in 1 BLISTER PACK (0299-4910-00) > 2 g in 1 TUBE

• 0299- Galderma Laboratories, L.P.
  • 0299-4910- Differin
    • 0299-4910-15- 1 TUBE in 1 CARTON (0299-4910-15) > 15 g in 1 TUBE

• 0299- Galderma Laboratories, L.P.
  • 0299-4910- Differin
    • 0299-4910-45- 1 TUBE in 1 CARTON (0299-4910-45) > 45 g in 1 TUBE

• 0299- Galderma Laboratories, L.P.
  • 0299-5912- Differin
    • 0299-5912-01- 15 mL in 1 BOTTLE (0299-5912-01)

• 0299- Galderma Laboratories, L.P.
  • 0299-5912- Differin
    • 0299-5912-02- 1 BOTTLE, PUMP in 1 CARTON (0299-5912-02) > 59 mL in 1 BOTTLE, PUMP

• 0299- GALDERMA LABORATORIES, L.P
  • 0299-5915- Differin
    • 0299-5915-45- 1 TUBE in 1 CARTON (0299-5915-45) > 45 g in 1 TUBE

• 0299- Galderma Laboratories, L.P.
  • 0299-5918- DIFFERIN
    • 0299-5918-02- 2 g in 1 TUBE (0299-5918-02)

• 0299- Galderma Laboratories, L.P.
  • 0299-5918- DIFFERIN
    • 0299-5918-15- 1 TUBE in 1 CARTON (0299-5918-15) > 15 g in 1 TUBE

• 0299- Galderma Laboratories, L.P.
  • 0299-5918- DIFFERIN
    • 0299-5918-25- 1 BOTTLE, PUMP in 1 CARTON (0299-5918-25) > 45 g in 1 BOTTLE, PUMP

• 0299- Galderma Laboratories, L.P.
  • 0299-5918- DIFFERIN
    • 0299-5918-45- 1 TUBE in 1 CARTON (0299-5918-45) > 45 g in 1 TUBE

• 0472- Actavis Pharma, Inc.
  • 0472-0126- adapalene
    • 0472-0126-45- 1 TUBE in 1 CARTON (0472-0126-45) > 45 g in 1 TUBE

• 0682- Marnel Pharmaceuticals, Inc.
  • 0682-0053- Adapalene Topical Solution
    • 0682-0053-14- 14 POUCH in 1 CARTON (0682-0053-14) > 1.2 mL in 1 POUCH

• 0682- Marnel Pharmaceuticals, Inc.
  • 0682-0053- Adapalene Topical Solution
    • 0682-0053-30- 30 POUCH in 1 CARTON (0682-0053-30) > 1.2 mL in 1 POUCH

• 0781- Sandoz Inc.
  • 0781-7142- Adapalene
    • 0781-7142-19- 1 TUBE in 1 CARTON (0781-7142-19) > 45 g in 1 TUBE

• 0781- Sandoz Inc.
  • 0781-7142- Adapalene
    • 0781-7142-70- 1 BOTTLE, PUMP in 1 BOTTLE, PUMP (0781-7142-70) > 45 g in 1 BOTTLE, PUMP

• 11410- The Proactiv Company, LLC
  • 11410-956- Proactiv MD Adapalene Acne Treatment
    • 11410-956-17- 1 TUBE in 1 BOX (11410-956-17) > 45 g in 1 TUBE

• 11410- The Proactiv Company, LLC
  • 11410-956- Proactiv MD Adapalene Acne Treatment
    • 11410-956-38- 1 TUBE in 1 BLISTER PACK (11410-956-38) > 2 g in 1 TUBE

• 11410- The Proactiv Company, LLC
  • 11410-956- Proactiv MD Adapalene Acne Treatment
    • 11410-956-44- 1 TUBE in 1 BOX (11410-956-44) > 15 g in 1 TUBE

• 21130- Safeway, Inc.
  • 21130-708- Adapalene
    • 21130-708-05- 1 TUBE in 1 CARTON (21130-708-05) > 15 g in 1 TUBE

• 28595- Allegis Pharmaceuticals, LLC
  • 28595-530- Adapalene
    • 28595-530-60- 1 BOTTLE, GLASS in 1 CARTON (28595-530-60) > 60 mL in 1 BOTTLE, GLASS

• 42546- PruGen, Inc.
  • 42546-720- Adapalene
    • 42546-720-45- 1 TUBE in 1 CARTON (42546-720-45) > 45 g in 1 TUBE

• 45802- Perrigo New York Inc
  • 45802-453- Adapalene
    • 45802-453-84- 1 TUBE in 1 CARTON (45802-453-84) > 45 g in 1 TUBE

• 49908- CALL INC. (dba Rochester Pharmaceuticals)
  • 49908-118- Adapalene
    • 49908-118-14- 14 POUCH in 1 CARTON (49908-118-14) > 1.2 mL in 1 POUCH (49908-118-00)

• 49967- LíOreal USA Products Inc
  • 49967-354- Adapalene
    • 49967-354-01- 1 TUBE in 1 CARTON (49967-354-01) > 45 g in 1 TUBE

• 49967- LíOreal USA Products Inc
  • 49967-354- Adapalene
    • 49967-354-02- 1 TUBE in 1 CARTON (49967-354-02) > 15 g in 1 TUBE

• 50090- A-S Medication Solutions
  • 50090-2004- Adapalene
    • 50090-2004-0- 45 g in 1 TUBE (50090-2004-0)

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-1377- Adapalene
    • 51672-1377-6- 1 TUBE in 1 CARTON (51672-1377-6) > 45 g in 1 TUBE

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-1377- Adapalene
    • 51672-1377-9- 1 BOTTLE, PUMP in 1 CARTON (51672-1377-9) > 45 g in 1 BOTTLE, PUMP

• 66993- Prasco Laboratories
  • 66993-884- ADAPALENE
    • 66993-884-45- 1 TUBE in 1 CARTON (66993-884-45) > 45 g in 1 TUBE

• 66993- Prasco Laboratories
  • 66993-884- ADAPALENE
    • 66993-884-48- 1 BOTTLE, PUMP in 1 CARTON (66993-884-48) > 45 g in 1 BOTTLE, PUMP

• 68462- Glenmark Pharmaceuticals Inc., USA
  • 68462-403- Adapalene
    • 68462-403-55- 45 g in 1 TUBE (68462-403-55)

• 69842- CVS Pharmacy
  • 69842-088- Adapalene
    • 69842-088-05- 1 TUBE in 1 CARTON (69842-088-05) > 15 g in 1 TUBE

• 69842- CVS Pharmacy
  • 69842-088- Adapalene
    • 69842-088-16- 1 TUBE in 1 CARTON (69842-088-16) > 45 g in 1 TUBE