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Spectrum:
Absorption: Readily absorbed after oral administration. Absorption is slower but more complete with macrocrystals (Macrodantin).
Distribution: Crosses placenta; enters breast milk.
Protein Binding: 40%.
Metabolism/Excretion: Partially metabolized by the liver; 30–50% excreted unchanged by the kidneys.
Half-life: 20 min (↑ in renal impairment).
Contraindicated in:
Use Cautiously in:
EENT: nystagmus.
Resp: PNEUMONITIS, PULMONARY FIBROSIS.
CV: chest pain.
GI: HEPATOTOXICITY, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), anorexia, nausea, vomiting, abdominal pain, diarrhea.
GU: rust/brown discoloration of urine.
Derm: photosensitivity.
Hemat: blood dyscrasias, hemolytic anemia.
Neuro: peripheral neuropathy , dizziness, drowsiness, headache.
Misc: hypersensitivity reactions.
Drug-Drug:
(Generic available)
NDC Code*