rye-ba-VYE-rin 
Absorption: Systemic absorption occurs following nasal and oral inhalation. Rapidly and extensively absorbed following oral administration, but undergoes first-pass hepatic metabolism (64% bioavailability).
Distribution: 70% of inhaled drug is deposited in the respiratory tract. Appears to concentrate in the respiratory tract and red blood cells. Enters breast milk.
Metabolism/Excretion: Eliminated from the respiratory tract by distribution across membranes, macrophages, and ciliary motion. Metabolized primarily by the liver; metabolites are renally excreted.
Half-life: Inhaln — 9.5 hr (40 days in RBCs); oral — 43.6 hr (single dose); 12 days (multiple dose).
Contraindicated in:
Use Cautiously in:
Inhalation
CV: CARDIAC ARREST, hypotension.
Derm: rash.
EENT: blurred vision, conjunctivitis, erythema of the eyelids, ocular irritation, photosensitivity.
Hemat: hemolytic anemia, reticulocytosis.
Oral
CNS: HOMICIDAL IDEATION, SUICIDAL IDEATION/ATTEMPTS, depression, aggressive behavior, emotional lability (↑ in children), fatigue (↓ in children), impaired concentration (↓ in children), insomnia (↓ in children), irritability (↓ in children).
Derm: pruritus (↓ in children).
EENT: dry mouth, optic neuritis, papilledema, retinal artery/vein thrombosis, retinal detachment, retinal hemorrhage, retinopathy (with macular edema), visual abnormalities.
GI: anorexia (↑ in children), dyspepsia (↓ in children), vomiting (↑ in children).
GU: ↓fertility (males).
Hemat: hemolytic anemia.
MS: arthralgia (↓ in children).
Neuro: dizziness, faintness.
Resp: dyspnea (↓ in children).
Misc: fever (↑ in children).
Drug-Drug:
RSV Infection
Chronic Hepatitis C
Viral Genotype 1 or 4
75 kg): 600 mg twice daily for 48 wk.5 yr and 75 kg): 600 mg in the morning, then 600 mg in the evening for 48 wk.5 yr and 60–74 kg): 400 mg in the morning, then 600 mg in the evening for 48 wk.5 yr and 47–59 kg): 400 mg in the morning, then 400 mg in the evening for 48 wk.5 yr and 34–46 kg): 200 mg in the morning, then 400 mg in the evening for 48 wk.5 yr and 23–33 kg): 200 mg in the morning, then 200 mg in the evening for 48 wk.Renal Impairment
5 yr and 75 kg): 600 mg in the morning, then 600 mg in the evening for 24 wk.5 yr and 60–74 kg): 400 mg in the morning, then 600 mg in the evening for 24 wk.5 yr and 47–59 kg): 400 mg in the morning, then 400 mg in the evening for 24 wk.5 yr and 34–46 kg): 200 mg in the morning, then 400 mg in the evening for 24 wk.5 yr and 23–33 kg): 200 mg in the morning, then 200 mg in the evening for 24 wk.Renal Impairment
Copegus, Rebetol, Virazole
NDC Code*