ta-DA-la-fil 
Absorption: Well absorbed following oral administration.
Distribution: Extensive tissue distribution; penetrates semen.
Protein Binding: 94%.
Metabolism/Excretion: Mostly metabolized by the liver (mainly CYP3A4 enzyme system); metabolites are excreted in feces (61%) and urine (36%).
Half-life: 17.5 hr.
Contraindicated in:
Use Cautiously in:
CV: hypotension, peripheral edema.
Derm: flushing.
EENT: hearing loss, nasal congestion, vision loss.
GI: diarrhea, dyspepsia.
GU: ↓fertility, priapism.
MS: back pain, limb pain, myalgia.
Neuro: headache.
Drug-Drug:
1 day before starting Cialis for BPH.Cialis (for ED)
Renal Impairment
Hepatic Impairment
Cialis (for BPH or ED/BPH)
Renal Impairment
Hepatic Impairment
Adcirca and Alyq (for pulmonary arterial hypertension)
1 wk — start 20 mg once daily; may then ↑ to 40 mg once daily based on tolerability; If initiating ritonavir while on Adcirca or Alyq — stop Adcirca or Alyq 24 hr before starting ritonavir; may reinitiate Adcirca or Alyq at 20 mg once daily after 1 wk of therapy with ritonavir; may then ↑ to 40 mg once daily based on tolerability.Renal Impairment
Hepatic Impairment
Therapeutic Classification: erectile dysfunction agents, vasodilators
Pharmacologic Classification: phosphodiesterase type 5 inhibitors
5 units) in combination with tadalafil; may increase risk of orthostatic hypotension, increased heart rate, decreased standing BP, dizziness, headache.NDC Code*
