so-li-FEN-a-sin 
Absorption: Well absorbed (90%).
Distribution: Extensively distributed to tissues.
Protein Binding: 98%.
Metabolism/Excretion: Extensively metabolized by the CYP3A4 isoenzyme. 69% excreted in urine as metabolites, 22% in feces.
Half-life: Tablets — 45–68 hr; Suspension — 26 hr.
Contraindicated in:
Use Cautiously in:
CV: palpitations, QT interval prolongation, tachycardia.
EENT: blurred vision.
GI: constipation, dry mouth, abdominal pain, dyspepsia, nausea.
MS: muscle weakness.
Neuro: confusion, drowsiness, hallucinations, headache.
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMIA).
Drug-Drug:
Overactive Bladder
Renal Impairment
Hepatic Impairment
Neurogenic Detrusor Overactivity
2 yr and >60 kg): Suspension — 5 mg once daily, may ↑ to 10 mg once daily; Concurrent use of strong CYP3A4 inhibitors — Suspension: Not to exceed 5 mg once daily.2 yr and 46–60 kg): Suspension — 4 mg once daily, may ↑ to 8 mg once daily; Concurrent use of strong CYP3A4 inhibitors — Suspension: Not to exceed 4 mg once daily.2 yr and 31–45 kg): Suspension — 3 mg once daily, may ↑ to 6 mg once daily; Concurrent use of strong CYP3A4 inhibitors — Suspension: Not to exceed 3 mg once daily.2 yr and 16–30 kg): Suspension — 3 mg once daily, may ↑ to 5 mg once daily; Concurrent use of strong CYP3A4 inhibitors — Suspension: Not to exceed 3 mg once daily.2 yr and 9–15 kg): Suspension — 2 mg once daily, may ↑ to 4 mg once daily; Concurrent use of strong CYP3A4 inhibitors — Suspension: Not to exceed 2 mg once daily.Renal Impairment
2 yr): CCr <30 mL/min — >60 kg: Not to exceed 5 mg once daily (suspension); 46–60 kg: Not to exceed 4 mg once daily (suspension); 16–45 kg: Not to exceed 3 mg once daily (suspension); 9–15 kg: Not to exceed 2 mg once daily (suspension).Hepatic Impairment
2 yr): Moderate hepatic impairment — >60 kg: Not to exceed 5 mg once daily (suspension); 46–60 kg: Not to exceed 4 mg once daily (suspension); 16–45 kg: Not to exceed 3 mg once daily (suspension); 9–15 kg: Not to exceed 2 mg once daily (suspension).Therapeutic Classification: urinary tract antispasmodics
Pharmacologic Classification: anticholinergics
(Generic available)
NDC Code*