Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.
REMS
- PO: Hypertension, hyperlipidemia, cardiovascular disease prevention, colorectal and gastric cancer prevention
- Topical: Dermal fungal infections including tinea corporis, cruris, and pedis.
Absorption: Garlic oil is well absorbed.
Distribution: Unknown.
Metabolism/Excretion: Kidney and lungs.
Half-life: Unknown.
GI: Irritation of the mouth, esophagus, and stomach, nausea, bad breath, vomiting, flatulence, diarrhea.
Derm: Contact dermatitis and other allergic reactions (asthma, rash, anaphylaxis [rare]), Diaphoresis.
Hemat: Chronic use or excessive dose may lead to ↓ hemoglobin production and lysis of RBCs, platelet dysfunction, prolonged bleeding time.
Neuro: dizziness.
Misc: body odor.
Natural-Drug Products:
- Use of garlic with anticoagulants, antiplatelet agents, and thrombolytics may ↑ risk of bleeding.
- May ↓ the effectiveness of contraceptive drugs and cyclosporine.
- May ↓ plasma concentrations of saquinavir, nevirapine, delavirdine, and efavirenz.
- May ↓ isoniazid levels by 65%.
Natural-Natural Products:
- Herbs with anticoagulant or antiplatelet properties may increase bleeding risk when combined with garlic, including: angelica, anise, asafoetida, bogbean, boldo, capsicum, celery, chamomile, clove, danshen, dong quai, fenugreek, feverfew, ginger, ginkgo, Panax ginseng, horse chestnut, horseradish, licorice, meadowsweet, prickly ash, onion, papain, passionflower, poplar, quassia, red clover, turmeric, wild carrot, wild lettuce, willow, and others.
Alli sativa bulbus, Allium sativum
Therapeutic Classification: lipid-lowering agents
