mel-uh-TOH-nin

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

• Sleep disorders (including insomnia, jet lag and circadian rhythm disorders)

• Melatonin is a hormone secreted from the pineal gland in a 24-hour circadian rhythm, regulating the normal sleep/wake cycle. As a supplement, melatonin has both phase-shifting and sleep-promoting properties. In addition to promoting sleep, physiologic roles of melatonin include regulation of the secretion of growth hormone and gonadotropic hormones. It also possesses antioxidant activity.

• Improved sleep pattern.

Absorption: Unknown.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-life: Unknown.

Contraindicated in:

• Hypersensitivity
• Pregnancy and lactation.

Use Cautiously in:

• Seizure disorders
• Diabetes
• Hypertension.

CV: hypotension.

CNS: drowsiness, headache, dizziness.

GI: nausea, vomiting, abdominal cramps.

Natural-Drug Products:

• Additive sedation with CNS depressants..
• May increase bleeding risk with antiplatelet agents and anticoagulants..
• May interfere with the glucose lowering effects of hypoglycemic agents..
• May decrease effectiveness of nifedipine..

Natural-Natural Products:

• May have additive sedative effects with herbs that have sedative properties including5–HTP,kava,St.John's wort,valerianand others.
• May increase risk of bleeding with herbs that have antiplatelet/anticoagulant properties such asclove, garlic,ginger,gingko,ginsengand others.

• PO (Adults): 0.3–10 mg daily at bedtime.

• PO: Administer before bedtime.

pineal hormone, N-acetyl-5–methoxtryptamine

Therapeutic Classification: sedative/hypnotics

• Capsules: Tablets: 3 mg;

• Assess sleep patterns before and periodically throughout therapy.

• Monitor blood glucose, coagulation panel, hormone panel, and lipid panel periodically during therapy.

• (Indications).

• Instruct patient to take at bedtime as directed.
• Causes drowsiness. Caution patient to avoid driving and other activities requiring alertness until response to medication is known.
• Caution patient to avoid concurrent use of alcohol or other CNS depressants.
• Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

• Relief of insomnia.

NDC Code^*

• 43742- Deseret Biologicals, Inc.
  • 43742-0205- Melatonin
    • 43742-0205-1- 30 mL in 1 BOTTLE, DROPPER (43742-0205-1)

• 43742- Deseret Biologicals, Inc.
  • 43742-0771- Melatonin
    • 43742-0771-1- 30 mL in 1 BOTTLE, DROPPER (43742-0771-1)

• 43857- BioActive Nutritional, Inc.
  • 43857-0086- Melatonin
    • 43857-0086-1- 30 mL in 1 BOTTLE, DROPPER (43857-0086-1)

• 43857- BioActive Nutritional, Inc.
  • 43857-0511- Melatonin
    • 43857-0511-1- 30 mL in 1 BOTTLE, DROPPER (43857-0511-1)

• 44911- Energique, Inc.
  • 44911-0194- MELATONIN CORD
    • 44911-0194-1- 30 mL in 1 BOTTLE, DROPPER (44911-0194-1)

• 44911- Energique, Inc.
  • 44911-0247- Melatonin Phenolic
    • 44911-0247-1- 30 mL in 1 BOTTLE, DROPPER (44911-0247-1)