Absorption: Following absorption, rapidly converted to ezetimibe-glucuronide, which is active. Bioavailability is variable.
Distribution: Unknown.
Metabolism/Excretion: Undergoes enterohepatic recycling, mostly eliminated in feces, minimal renal excretion.
Half-life: 22 hr.
Contraindicated in:
Use Cautiously in:
Derm: rash.
GI: cholecystitis, cholelithiasis, ↑ liver enzymes (with HMG-CoA reductase inhibitors), nausea, pancreatitis.
Misc: ANGIOEDEMA.
Drug-Drug:
Renal Impairment
Therapeutic Classification: lipid-lowering agents
Pharmacologic Classification: cholesterol absorption inhibitors
(Generic available)
NDC Code*