Oropharyngeal Candidiasis
- PO, IV (Adults): 200 mg initially, then 100 mg daily for at least 2 wk.
- PO, IV (Children >14 days): 6 mg/kg initially, then 3 mg/kg/day for at least 2 wk.
- PO, IV (Neonates <14 days, 30–36 wk gestation): same dose as older children except frequency is every 48 hr; Premature neonates <29 wk gestation: 5–6 mg/kg/dose every 48–72 hr.
Renal Impairment
- PO, IV (Adults): CCr ≤50 mL/min (no hemodialysis): Give 50% of the usual dose; Hemodialysis: Give 100% of the usual dose after each dialysis session; give reduced dose based on CCr on non-dialysis days.
Esophageal Candidiasis
- PO, IV (Adults): 200 mg initially, then 100 mg once daily for at least 3 wk (up to 400 mg/day).
- PO, IV (Children >14 days): 6 mg/kg initially, then 3–12 mg/kg/day for at least 3 wk.
- PO, IV (Neonates <14 days, 30–36 wk gestation): same dose as older children except frequency is every 48 hr; Premature neonates <29 wk gestation: 5–6 mg/kg/dose every 48–72 hr.
Renal Impairment
- PO, IV (Adults): CCr ≤50 mL/min (no hemodialysis): Give 50% of the usual dose; Hemodialysis: Give 100% of the usual dose after each dialysis session; give reduced dose based on CCr on non-dialysis days.
Vaginal Candidiasis
- PO (Adults): 150-mg single dose; prevention of recurrence (unlabeled)—150 mg daily for 3 days then weekly for 6 mo.
Systemic Candidiasis
- PO, IV (Adults): 400 mg/day initially, then 200–800 mg/day for 28 days.
- PO, IV (Children >14 days): 6–12 mg/kg/day for 28 days.
- PO, IV (Neonates <14 days, 30–36 wk gestation): same dose as older children except frequency is every 48 hr; Premature neonates <29 wk gestation: 5–6 mg/kg/dose every 48–72 hr.
Renal Impairment
- PO, IV (Adults): CCr ≤50 mL/min (no hemodialysis): Give 50% of the usual dose; Hemodialysis: Give 100% of the usual dose after each dialysis session; give reduced dose based on CCr on non-dialysis days.
Cryptococcal Meningitis
- PO, IV (Adults): Treatment: 400 mg once daily until favorable clinical response, then 200–800 mg once daily for at least 10–12 wk after clearing of CSF; change to oral therapy as soon as possible. Suppressive therapy: 200 mg once daily.
- PO, IV (Children >14 days): 12 mg/kg/day initially, then 6–12 mg/kg/day for at least 10–12 wk after clearing of CSF; change to oral therapy as soon as possible. Suppressive therapy: 6 mg/kg/day.
- PO, IV (Neonates <14 days, 30–36 wk gestation): same dose as older children except frequency is every 48 hr; Premature neonates <29 wk gestation: 5–6 mg/kg/dose every 48–72 hr.
Renal Impairment
- PO, IV (Adults): CCr ≤50 mL/min (no hemodialysis): Give 50% of the usual dose; Hemodialysis: Give 100% of the usual dose after each dialysis session; give reduced dose based on CCr on non-dialysis days.
Prevention of Candidiasis after Bone Marrow Transplant
- PO, IV (Adults): 400 mg once daily; begin several days before procedure if severe neutropenia is expected, and continue for 7 days after ANC >1000 /mm3.
- PO, IV (Children >14 days): 10–12 mg/kg/day, not to exceed 600 mg/day.
Renal Impairment
- PO, IV (Adults): CCr ≤50 mL/min (no hemodialysis): Give 50% of the usual dose; Hemodialysis: Give 100% of the usual dose after each dialysis session; give reduced dose based on CCr on non-dialysis days.
