section name header

Pronunciation ⬇

fa-MOE-ti-deen audio

Classifications ⬆ ⬇

Therapeutic Classification: antiulcer agents

Pharmacologic Classification: histamine h2 antagonists

Indications ⬆ ⬇

REMS

Unlabeled Use:

Action ⬆ ⬇

Therapeutic Effects:

Pharmacokinetics ⬆ ⬇

Absorption: 40–45% absorbed following oral administration.

Distribution: Enters breast milk and cerebrospinal fluid.

Protein Binding: 15–20%.

Metabolism/Excretion: Up to 70% excreted unchanged by the kidneys, 30–35% metabolized by the liver.

Half-life: Infants: 4.5–15 hr; Children: 3.3–5.7 hr; Adults: 2.5–3.5 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
POwithin 60 min1–4 hr6–12 hr
IVwithin 60 min0.5–3 hr8–15 hr

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: ARRHYTHMIAS.

Endo: gynecomastia.

GI: constipation, diarrhea, nausea.

GU: ↓sperm count, erectile dysfunction.

Hemat: AGRANULOCYTOSIS, APLASTIC ANEMIA, anemia, neutropenia, thrombocytopenia.

Local: pain at IM site.

Neuro: confusion, dizziness, drowsiness, hallucinations, headache.

Interactions ⬆ ⬇

Drug-Drug:

Route/Dosage ⬆ ⬇

see Calculator

Renal Impairment

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Pepcid, Pepcid AC

Pot. Nursing Diagnoses ⬆ ⬇

Code ⬆

NDC Code*