SILL-i-yum

Therapeutic Classification: laxatives

Pharmacologic Classification: bulk forming agents

• Management of simple or chronic constipation, particularly if associated with a low-fiber diet.
• Useful in situations in which straining should be avoided (after MI, rectal surgery, prolonged bed rest).
• Used in the management of chronic watery diarrhea.

• Combines with water in the intestinal contents to form an emollient gel or viscous solution that promotes peristalsis and reduces transit time.

• Relief and prevention of constipation.

Absorption: Not absorbed from the GI tract.

Distribution: No distribution occurs.

Metabolism/Excretion: Excreted in feces.

Half-life: Unknown.

(laxative effect)

Contraindicated in:

• Hypersensitivity
• Abdominal pain, nausea, or vomiting (especially when associated with fever)
• Serious adhesions
• Dysphagia.

Use Cautiously in:

• Some dosage forms contain sugar, aspartame, or excessive sodium and should be avoided in patients on restricted diets
• OB: Lactation: Has been used safely.

Resp: bronchospasm.

GI: cramps, intestinal or esophageal obstruction, nausea, vomiting.

Drug-Drug:

• May ↓ absorption of warfarin, salicylates, or digoxin.

• PO (Adults): 1–2 tsp/packet/wafer (3–6 g psyllium) in or with a full glass of liquid 2–3 times daily. Up to 30 g daily in divided doses.
• PO (Children >6 yr): 1 tsp/packet/wafer (1.5–3 g psyllium) in or with 4–8 oz glass of liquid 2–3 times daily. Up to 15 g daily in divided doses.

(Generic available)

• Powder: 3.3–3.5 g/dose or packet^OTC;
• Effervescent powder: 3–3.5 g/dose or packet^OTC;
• Granules: 2.5 g/dose^OTC;
• Wafers: 3.4 g/dose^OTC;

• Assess patient for abdominal distention, presence of bowel sounds, and usual pattern of bowel function.
• Assess color, consistency, and amount of stool produced.

• May cause elevated blood glucose levels with prolonged use of preparations containing sugar.

• Packets are not standardized for volume, but each contains 3–3.5 g of psyllium.
• PO: Administer with a full glass of water or juice, followed by an additional glass of liquid. Solution should be taken immediately after mixing; it will congeal. Do not administer without sufficient fluid and do not chew granules.

• Encourage patient to use other forms of bowel regulation, such as increasing bulk in the diet, increasing fluid intake, and increasing mobility. Normal bowel habits are individualized and may vary from 3 times/day to 3 times/wk.
• May be used for long-term management of chronic constipation.
• Instruct patients with cardiac disease to avoid straining during bowel movements (Valsalva maneuver).
• Advise patient not to use laxatives when abdominal pain, nausea, vomiting, or fever is present.

• A soft, formed bowel movement, usually within 12–24 hr. May require 3 days of therapy for results.

Alramucil, Cillium, Effer-Syllium, Fiberall, Fibrepur, Hydrocil, Konsyl, Metamucil, Modane Bulk, Mylanta Natural Fiber Supplement, Naturacil Caramels, Perdiem, Pro-Lax, Reguloid Natural, Serutan, Siblin, Syllact, Vitalax, V-Lax

Karacil, Natural Source Fibre Laxative, Prodiem

• Constipation (Indications).

NDC Code^*

• 0536- Rugby Laboratories
  • 0536-1881- Reguloid
    • 0536-1881-16- 426 g in 1 BOTTLE (0536-1881-16)

• 0536- Rugby Laboratories
  • 0536-1881- Reguloid
    • 0536-1881-79- 284 g in 1 BOTTLE (0536-1881-79)

• 0536- Rugby Laboratories
  • 0536-4444- Reguloid
    • 0536-4444-54- 369 g in 1 BOTTLE (0536-4444-54)

• 0536- Rugby Laboratories
  • 0536-4444- Reguloid
    • 0536-4444-89- 540 g in 1 BOTTLE (0536-4444-89)

• 0536- Rugby Laboratories
  • 0536-4445- Reguloid
    • 0536-4445-54- 368 g in 1 BOTTLE (0536-4445-54)

• 0536- Rugby Laboratories
  • 0536-4445- Reguloid
    • 0536-4445-89- 538 g in 1 BOTTLE (0536-4445-89)

• 57896- GERI-CARE PHARMACEUTICAL CORP
  • 57896-471- ORANGE FLAVOR GERI-MUCIL
    • 57896-471-13- 368 g in 1 BOTTLE (57896-471-13)

• 57896- GERI-CARE PHARMACEUTICAL CORP
  • 57896-481- SUGAR FREE GERI-MUCIL
    • 57896-481-10- 283 g in 1 BOTTLE (57896-481-10)

• 68071- NuCare Pharmaceuticals,Inc.
  • 68071-1766- ORANGE FLAVOR GERI-MUCIL
    • 68071-1766-1- 368 g in 1 BOTTLE (68071-1766-1)

• 68788- Preferred Pharmaceuticals Inc.
  • 68788-7129- Reguloid
    • 68788-7129-3- 369 g in 1 BOTTLE (68788-7129-3)