VYE-ta-min E

Therapeutic Classification: vitamins

Pharmacologic Classification: fat soluble vitamins

• PO: Used as a dietary supplement.
• Used in low-birth-weight infants to prevent and treat hemolysis due to vitamin E deficiency.
• Topical: Treatment of irritated, chapped, or dry skin.

• Prevents the oxidation (antioxidant) of other substances.
• Protects RBC membranes against hemolysis, especially in low-birth-weight neonates.

• Prevention and treatment of deficiency in high-risk patients.

Absorption: 20–80% absorbed following oral administration. Absorption requires fat and bile salts.

Distribution: Widely distributed, stored in adipose tissue (4-yr supply).

Metabolism/Excretion: Metabolized by the liver, excreted in bile.

Half-life: Unknown.

Contraindicated in:

• Hypersensitivity to ingredients in preparations (parabens, propylene, glycol).

Use Cautiously in:

• Anemia due to iron deficiency
• Vitamin K deficiency (may ↑ risk of bleeding)
• Pedi: Oral administration may cause necrotizing enterocolitis in low-birth-weight infants.

Seen primarily with large doses over long periods of time

CNS: fatigue, headache, weakness.

EENT: blurred vision.

GI: NECROTIZING ENTEROCOLITIS (ORAL ADMINISTRATION IN LOW-BIRTH-WEIGHT INFANTS), cramps, diarrhea, nausea.

Derm: rash.

Endo: gonadal dysfunction.

Drug-Drug:

• Cholestyramine, colestipol, orlistat, mineral oil, and sucralfate↓ absorption.
• May ↓ hematologic response to iron supplements.
• May ↑ the risk of bleeding with warfarin or aspirin.

Drug-Natural Products:

• ↑bleeding risk with anise, arnica, chamomile, clove, dong quai, fenugreek, feverfew, garlic, ginger, ginkgo, Panax ginseng, licorice, and others.

• PO (Adults and Children): Determined by nutritional intake or degree of deficiency.
• Topical (Adults and Children): Apply to affected areas as needed.

• Capsules: 100 units^OTC; 200 units^OTC; 400 units^OTC; 600 units^OTC; 800 units^OTC; 1000 units^OTC;
• Oral solution: 26.6 units/mL^OTC; 50 units/mL^OTC; 77 units/mL^OTC;
• Tablets: 100 units^OTC; 200 units^OTC; 400 units^OTC; 500 units^OTC; 800 units^OTC;
• Chewable tablets: 400 units^OTC;
• Ointment: ^OTC;
• Cream: ^OTC;
• Lotion: ^OTC;
• Oil: ^OTC;

• Assess patient for signs of vitamin E deficiency (neonates — irritability, edema, hemolytic anemia, creatinuria; adults/children [rare] — muscle weakness, ceroid deposits, anemia, creatinuria) prior to and periodically throughout therapy.
• Assess nutritional status through 24-hr diet recall. Determine frequency of consumption of vitamin E–rich foods.

• Large doses may increase cholesterol, triglyceride, and CPK levels.

• PO: Administer with or after meals.
  • Chewable tablets should be chewed well or crushed before swallowing. Solution may be dropped directly into mouth or mixed with cereal, fruit juice, or other food. Use calibrated dropper supplied by manufacturer to measure solution accurately.

• Instruct patient to take medication as directed. If a dose is missed, it should be omitted, because fat-soluble vitamins are stored in the body for long periods.
• Encourage patient to comply with diet recommendations of health care professional. Explain that the best source of vitamins is a well-balanced diet with foods from the four basic food groups.
• Foods high in vitamin E include vegetable oils, wheat germ, whole-grain cereals, egg yolk, and liver. Vitamin E content is not markedly affected by cooking.
• Patients self-medicating with vitamin supplements should be cautioned not to exceed RDA. The effectiveness of megadoses for treatment of various medical conditions is unproved, and this may cause side effects and toxicity.
• Review symptoms of overdosage (blurred vision, flu-like symptoms, headache, breast enlargement). Instruct patient to report these promptly to health care professional.
• Mineral oil may interfere with the absorption of fat-soluble vitamins and should not be used concurrently.

• Prevention of or decrease in the symptoms of vitamin E deficiency.
• Control of dry or chapped skin.

alpha tocopherol, Amino-Opti-E, Aquasol E, E-200, E-400, E-1000, E-Complex-600, E-Vitamin, Liqui-E, Pheryl-E, Vita Plus E

Webber Vitamin E

• Imbalanced nutrition: less than body requirements (Indications).

NDC Code^*

• 70236- NeoBiotech Global Corporation
  • 70236-103- Acne C-Patch
    • 70236-103-02- 7 PATCH in 1 POUCH (70236-103-02) > 2 g in 1 PATCH (70236-103-01)