VUH-lare-ee-en

Therapeutic Classification: antianxiety agents, sedative/hypnotics

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

• Insomnia
• Anxiety

• May increase concentrations of the inhibitory CNS transmitter GABA.

• Improvement in sleep quality.

Absorption: Unknown.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-life: Unknown.

Contraindicated in:

• Pregnancy and lactation.

Use Cautiously in:

• Alcohol use (may have additive sedative effects)
• Surgery (discontinue use 2 wk prior to elective procedures)
• Children (do not use longer than 8 wk).

CNS: drowsiness, headache.

GI: dry mouth.

Misc: Benzodiazepine-like withdrawal symptoms with discontinuation after long-term use.

Natural-Drug Products:

• Additive CNS depression with alcohol, antihistamines, anesthetic agents, sedative hypnotics, and other CNS depressants.
• Alcohol-containing preparations may interact with disulfiram and metronidazole.

Natural-Natural Products:

• Additive sedative effects can occur when used with herbal supplements with sedative properties such as kava, l-tryptophan, melatonin, SAMe, and St. John's wort.

• PO (Adults): Tea—1 cup tea 1–5 times daily. Tea is made by steeping 2–3 g root in 150 mL boiling water for 5–10 min then straining. Tincture—1–3 mL 1–5 times daily. Extract—400–900 mg up to 2 hr before bedtime or 300–450 mg divided tid.

• Capsules: ^OTC;
• Extract: ^OTC;
• Tea: ^OTC;
• Tincture: ^OTC;

• Assess degree of anxiety and level of sedation prior to and periodically throughout therapy.
• Assess sleep patterns.
• Assess response in the elderly population where drowsiness and loss of balance may pose a significant risk for injury.

• Take 1–2 hr before bedtime if used for nighttime hypnotic.
• Administer orally three to five times daily to control anxiety.

• Encourage patients to avoid stimulants such as caffeine and to provide an environment that promotes restful sleep.
• May cause drowsiness. Caution patient to avoid driving or other activities requiring alertness until response to drug is known.
• Caution patient to avoid use of alcohol and other medications or herbals that have a sedative effect; may increase drowsiness.
• Advise patients to discontinue 2 wk prior to elective surgical procedures.
• Inform patients that dependence with withdrawal symptoms may develop with prolonged use.
• Rep: Advise females of reproductive potential to avoid valerian if pregnancy is planned or suspected or breastfeeding.

• Decreased anxiety level.
• Improvement in sleep with a feeling of restfulness without drowsiness upon awakening.

Amantilla, All-Heal, Baldrian, Baldrianwurzel, Belgium Valerian, Common Valerian, Fragrant Valerian, Garden Heliotrope, Garden Valerian, Indian Valerian, Mexican Valerian, Pacific Valerian, Tagara, Valeriana, Valeriana officinalis, Valerianae radix, Valeriana rhizome, Valeriane

NDC Code^*

• 0220- Boiron
  • 0220-5207- VALERIANA OFFICINALIS
    • 0220-5207-41- 6 [hp_C] in 1 TUBE (0220-5207-41)

• 0220- Boiron
  • 0220-5208- VALERIANA OFFICINALIS
    • 0220-5208-41- 9 [hp_C] in 1 TUBE (0220-5208-41)

• 0220- Boiron
  • 0220-5209- VALERIANA OFFICINALIS
    • 0220-5209-41- 30 [hp_C] in 1 TUBE (0220-5209-41)

• 0220- Boiron
  • 0220-5210- VALERIANA OFFICINALIS
    • 0220-5210-41- 30 [hp_X] in 1 TUBE (0220-5210-41)

• 0220- Boiron
  • 0220-5217- Valeriana officinalis
    • 0220-5217-41- 80 PELLET in 1 TUBE (0220-5217-41)

• 13838- Phytodyne Inc.
  • 13838-1448- Valeriana officinalis (N)
    • 13838-1448-1- 20 mL in 1 BOTTLE, GLASS (13838-1448-1)

• 62106- Seroyal USA
  • 62106-9130- VALERIANA OFFICINALIS
    • 62106-9130-4- 10 TUBE in 1 CARTON (62106-9130-4) > 140 GRANULE in 1 TUBE

• 64117- Natural Health Supply
  • 64117-194- Insomnia Nervousness
    • 64117-194-01- 1.875 mL in 1 BOTTLE, GLASS (64117-194-01)

• 64117- Natural Health Supply
  • 64117-194- Insomnia Nervousness
    • 64117-194-02- 7.5 mL in 1 BOTTLE, GLASS (64117-194-02)

• 68428- Washington Homeopathic Products
  • 68428-165- Valeriana Officinalis Kit Refill
    • 68428-165-01- 750 PELLET in 1 VIAL, GLASS (68428-165-01)

• 68428- Washington Homeopathic Products
  • 68428-693- Valeriana Officinalis
    • 68428-693-03- 75 PELLET in 1 VIAL, GLASS (68428-693-03)

• 68428- Washington Homeopathic Products
  • 68428-693- Valeriana Officinalis
    • 68428-693-05- 150 PELLET in 1 VIAL, GLASS (68428-693-05)

• 68428- Washington Homeopathic Products
  • 68428-693- Valeriana Officinalis
    • 68428-693-06- 1200 PELLET in 1 BOTTLE, GLASS (68428-693-06)

• 68428- Washington Homeopathic Products
  • 68428-693- Valeriana Officinalis
    • 68428-693-11- 300 PELLET in 1 BOTTLE, GLASS (68428-693-11)

• 68428- Washington Homeopathic Products
  • 68428-693- Valeriana Officinalis
    • 68428-693-12- 600 PELLET in 1 BOTTLE, GLASS (68428-693-12)

• 71919- Washington Homeopathic Products
  • 71919-702- VALERIANA OFFICINALIS
    • 71919-702-07- 15 mL in 1 VIAL, GLASS (71919-702-07)

• 71919- Washington Homeopathic Products
  • 71919-702- VALERIANA OFFICINALIS
    • 71919-702-08- 30 mL in 1 VIAL, GLASS (71919-702-08)

• 71919- Washington Homeopathic Products
  • 71919-702- VALERIANA OFFICINALIS
    • 71919-702-09- 50 mL in 1 BOTTLE, GLASS (71919-702-09)

• 71919- Washington Homeopathic Products
  • 71919-702- VALERIANA OFFICINALIS
    • 71919-702-10- 100 mL in 1 BOTTLE, GLASS (71919-702-10)