Absorption: Well absorbed after oral administration.
Distribution: Widely distributed.
Protein Binding: >99%.
Metabolism/Excretion: Mostly metabolized by the liver; <1% excreted unchanged in urine.
Half-life: 6–7 hr (single dose); 7.3 hr (chronic dosing).
(analgesic effect)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO (analgesic) | 0.5 hr | 1–2 hr | 4–12 hr |
| PO (anti-inflammatory) | days–wk | unknown | 6–12 hr† |
Contraindicated in:
Use Cautiously in:
CV: HF, MI, STROKE, edema, hypertension, palpitations.
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), EXFOLIATIVE DERMATITIS, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, ecchymoses, flushing, hyperpigmentation, pruritus, rash, sweating.
EENT: blurred vision, photophobia, tinnitus.
GI: GI BLEEDING, dyspepsia, abdominal pain, constipation, diarrhea, drug-induced hepatitis, dry mouth, flatulence, gastritis, nausea, stomatitis, thirst, vomiting.
GU: dysuria, renal failure, urinary frequency.
Hemat: anemia, prolonged bleeding time, thrombocytopenia.
Neuro: depression, dizziness, drowsiness, insomnia, malaise, nervousness, syncope, weakness.
Resp: asthma.
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA), chills, fever.
Drug-Drug:
Drug-Natural Products:
(Generic available)
NDC Code*