flure-oh-YOOR-a-sill

Therapeutic Classification: antineoplastics

Pharmacologic Classification: antimetabolites

• IV: Used alone and in combination with other modalities (surgery, radiation therapy, other antineoplastics) in the treatment of:
  • Colorectal adenocarcinoma,
  • Breast adenocarcinoma,
  • Gastric adenocarcinoma,
  • Pancreatic adenocarcinoma.
• Topical: Multiple actinic (solar) keratoses and superficial basal cell carcinomas.

• Inhibits DNA and RNA synthesis by preventing thymidine production (cell-cycle S-phase–specific).

• Death of rapidly replicating cells, particularly malignant ones.

Absorption: Minimal absorption (5–10%) after topical application.

Distribution: Widely distributed; concentrates and persists in tumors.

Metabolism/Excretion: Metabolized by dihydropyrimidine dehydrogenase to a less toxic compound; inactive metabolites are excreted primarily in urine.

Half-life: 20 hr.

(IV = effects on blood counts, Top = dermatologic effects)

Contraindicated in:

• Hypersensitivity
• Dihydropyrimidine dehydrogenase deficiency (patients at ↑ risk of toxicity)
• OB: Pregnancy
• Lactation: Lactation.

Use Cautiously in:

• Infections
• Depressed bone marrow reserve
• Other chronic debilitating illnesses
• Obese patients, patients with edema or ascites (dose should be based on ideal body weight).
• Pedi: Safety and effectiveness not established in children.

More likely to occur with systemic use than with topical use

CV: CARDIOTOXICITY.

Derm: alopecia, maculopapular rash, local inflammatory reactions (topical only), melanosis of nails, nail loss, palmar-plantar erythrodysesthesia, phototoxicity.

Endo: sterility.

GI: diarrhea, nausea, stomatitis, vomiting.

Hemat: anemia, leukopenia, thrombocytopenia.

Local: thrombophlebitis.

Neuro: acute cerebellar dysfunction.

Misc: fever.

Drug-Drug:

• Combination chemotherapy with irinotecan may produce unacceptable toxicity (dehydration, neutropenia, sepsis).
• Additive bone marrow depression with other bone marrow depressants, including other antineoplastics and radiation therapy.
• May ↓ antibody response to live-virus vaccines and ↑ risk of adverse reactions.

Advanced Colorectal Cancer

• IV (Adults): In combination with leucovorin alone or leucovorin + oxaliplatin or irinotecan: 400 mg/m² as IV bolus on Day 1, then 2400–3000 mg/m² continuous infusion every 2 wk; In combination with leucovorin: 500 mg/m² as IV bolus 1 hr after leucovorin on Days 1, 8, 15, 22, 29, and 36 every 8 wk.

Breast Cancer

• IV (Adults): In combination with cyclophosphamide + epirubicin or cyclophosphamide + methotrexate: 500 mg/m² or 600 mg/m² on Days 1 and 28 every 28 days for 6 cycles.

Gastric Adenocarcinoma

• IV (Adults): As part of platinum-containing regimen: 200–1000 mg/m² as IV infusion (frequency of administration and number of cycles depends on specific regimen used).

Pancreatic Adenocarcinoma

• IV (Adults): In combination with leucovorin or as part of multidrug regimen: 400 mg/m² as IV bolus on Day 1, then 2400 mg/m² continuous infusion every 2 wk.

Actinic (Solar) Keratoses

• Topical (Adults): Carac: Apply 0.5% cream to lesions once daily for up to 4 wk; Efudex: Apply 2% or 5% solution or cream to lesions twice daily for 2–4 wk.

Superficial Basal Cell Carcinomas

• Topical (Adults): Efudex: Apply 5% solution or cream to lesions twice daily for 3–6 wk (up to 12 wk).

(Generic available)

• Solution for injection: 50 mg/mL;
• Topical cream: 0.5%; 4%; 5%;
• Topical solution: 2%; 5%;

• Monitor vital signs before and frequently during therapy.
  • Assess mucous membranes, number and consistency of stools, and frequency of vomiting. Assess for signs of infection (fever, chills, sore throat, cough, hoarseness, pain in lower back or side, difficult or painful urination). Assess for bleeding (bleeding gums; bruising; petechiae; and guaiac test stools, urine, and emesis). Avoid IM injections and taking rectal temperatures. Apply pressure to venipuncture sites for 10 min. Notify health care professional if Grade 3 or 4 toxicity (stomatitis or esophagopharyngitis, uncontrollable vomiting, diarrhea, GI bleeding, myocardial ischemia, leukocyte count <3500/mm³, platelet count <100,000/mm³, or hemorrhage from any site) occurs; hold fluorouracil until resolution to ≤Grade 1. May be reinitiated at a lower dose when side effects have subsided.
  • Assess IV site frequently for inflammation or infiltration. Patient should notify nurse if pain or irritation at injection site occurs. May cause thrombophlebitis. If extravasation occurs, infusion must be stopped and restarted in another vein to avoid damage to SUBQ tissue. Report immediately. Standard treatment includes application of ice compresses.
• Assess skin for palmar-plantar erythrodysesthesia (tingling of hands and feet followed by pain, erythema, swelling, desquamation) throughout therapy. Occurs more frequently with continuous infusion. Usually occurs after 8–9 wk of therapy, but may occur earlier. Hold fluorouracil for Grades 2 or 3 and resume at lower dose when resolved or Grade 1.
  • Monitor intake and output, appetite, and nutritional intake. GI effects usually occur on 4th day of therapy. Adjusting diet as tolerated may help maintain fluid and electrolyte balance and nutritional status and administering antidiarrheal agents. May cause severe diarrhea. Withhold therapy if Grade 3 or 4 diarrhea occurs and until resolved or decreased to Grade 1, then resume at reduced dose.
  • Monitor for cerebellar dysfunction (ataxia, confusion, disorientation, visual disturbances). This may persist after discontinuation of therapy.
  • Monitor for angina, myocardial infarction/ischemia, arrhythmia, and heart failure in patients with no history of coronary artery disease or myocardial dysfunction. Discontinue therapy if symptoms occur.
  • Monitor for signs and symptoms of hyperammonemic encephalopathy (altered mental status, confusion, disorientation, coma, ataxia) with ↑ serum ammonia level within 72 hrs of start of infusion. Discontinue fluorouracil and initiate ammonia-lowering therapy.
  • Assess for mucositis, stomatitis, and esophagopharyngitis during therapy. May lead to mucosal sloughing or ulceration. Occurs more frequently with IV bolus doses. If Grade 3 or 4 mucositis occurs, withhold dose and resume at reduced dose when resolved or reduced to Grade 1.
• Topical: Inspect involved skin before and throughout therapy.

• May cause ↓ in plasma albumin.
  • Monitor hepatic (AST, ALT, LDH, and serum bilirubin), renal, and hematologic (hematocrit, hemoglobin, leukocyte, platelet count) functions before each treatment and periodically during therapy.
  • Monitor CBC daily during IV therapy. Report WBC of <3500/mm³ or platelets <100,000/mm³ immediately; they are criteria for discontinuation. Nadir of leukopenia usually occurs in 9–14 days, with recovery by day 30. May also cause thrombocytopenia. Hold doses if Grade 4 myelosuppression occurs. Resume at reduced dose when resolved or improved to Grade 1.
  • May cause ↑ in urine excretion of 5-hydroxyindoleacetic acid (5-HIAA).
  • Monitor INR and prothrombin time in patients receiving concomitant warfarin; adjust anticoagulant dose accordingly.

• High Alert:Fatalities have occurred with incorrect administration of chemotherapeutic agents. Before administering, clarify all ambiguous orders; double-check single, daily, and course-of-therapy dose limits; have second practitioner independently double-check original order, calculations, and infusion pump settings. The number 5 in 5-fluorouracil is part of the drug name and does not refer to the dose.
• Prepare solution in a biologic cabinet. Wear gloves, gown, and mask while handling IV medication. Discard IV equipment in specially designated containers.
• When administering fluorouracil via IV push, 30 min of cryotherapy is recommended to prevent oral mucositis.

IV Administration:

• IV Push:
  Diluent: May be administered undiluted.Concentration: 50 mg/mL.
• Rate: Rapid IV push administration (over 1–2 min) is most effective, but there is a more rapid onset of toxicity.
• Intermittent Infusion:
  Diluent: May be diluted with D5W or 0.9% NaCl.
  • Use plastic IV tubing and IV bags to maintain greater stability of medication. Solution is stable for 24 hr at room temperature; do not refrigerate. Solution is colorless to faint yellow. Discard highly discolored or cloudy solution. If crystals form, dissolve by warming solution to 140°F, shaking vigorously, and cooling to body temperature.Concentration: Up to 50 mg/mL.
• Rate: Onset of toxicity is greatly delayed by administering an infusion over 2–8 hr.
• Y-Site Compatibility:
  • acyclovir
  • allopurinol
  • amifostine
  • amikacin
  • aminophylline
  • amphotericin B lipid complex
  • amphotericin B liposomal
  • ampicillin
  • ampicillin/sulbactam
  • anidulafungin
  • argatroban
  • azithromycin
  • aztreonam
  • bivalirudin
  • bleomycin
  • bumetanide
  • butorphanol
  • calcium gluconate
  • carboplatin
  • carmustine
  • cefazolin
  • cefepime
  • cefotaxime
  • cefotetan
  • cefoxitin
  • ceftazidime
  • ceftriaxone
  • cefuroxime
  • cisatracurium
  • cisplatin
  • clindamycin
  • cyclophosphamide
  • cyclosporine
  • dacarbazine
  • daptomycin
  • dexamethasone
  • dexmedetomidine
  • dexrazoxane
  • digoxin
  • docetaxel
  • dopamine
  • doxorubicin liposomal
  • enalaprilat
  • ephedrine
  • ertapenem
  • erythromycin
  • esmolol
  • etoposide phosphate
  • famotidine
  • fentanyl
  • fluconazole
  • fludarabine
  • foscarnet
  • fosphenytoin
  • furosemide
  • ganciclovir
  • gemcitabine
  • gentamicin
  • granisetron
  • heparin
  • hetastarch
  • hydrocortisone
  • hydromorphone
  • ifosfamide
  • imipenem/cilastatin
  • isoproterenol
  • ketorolac
  • labetalol
  • leucovorin calcium
  • lidocaine
  • linezolid
  • magnesium sulfate
  • mannitol
  • melphalan
  • meperidine
  • meropenem
  • mesna
  • methohexital
  • methotrexate
  • methylprednisolone
  • metoprolol
  • metronidazole
  • milrinone
  • mitomycin
  • mitoxantrone
  • morphine
  • nalbuphine
  • naloxone
  • nitroglycerin
  • nitroprusside
  • octreotide
  • paclitaxel
  • palonosetron
  • pamidronate
  • pantoprazole
  • pemetrexed
  • pentobarbital
  • phenobarbital
  • phenylephrine
  • piperacillin/tazobactam
  • potassium acetate
  • potassium phosphate
  • procainamide
  • propofol
  • propranolol
  • remifentanil
  • rituximab
  • sargramostim
  • sodium acetate
  • sodium bicarbonate
  • sodium phosphate
  • succinylcholine
  • sufentanil
  • tenoposide
  • theophylline
  • thiopental
  • thiotepa
  • tigecycline
  • tirofiban
  • tobramycin
  • trastuzumab
  • trimethoprim/sulfamethoxazole
  • vasopressin
  • vecuronium
  • vinblastine
  • vincristine
  • voriconazole
  • zidovudine
  • zoledronic acid
• Y-Site Incompatibility:
  • aldesleukin
  • amiodarone
  • amphotericin B deoxycholate
  • buprenorphine
  • calcium chloride
  • caspofungin
  • chlorpromazine
  • ciprofloxacin
  • diazepam
  • diltiazem
  • diphenhydramine
  • dobutamine
  • doxycycline
  • droperidol
  • epinephrine
  • epirubicin
  • filgrastim
  • haloperidol
  • hydroxyzine
  • idarubicin
  • irinotecan
  • levofloxacin
  • lorazepam
  • methadone
  • midazolam
  • minocycline
  • moxifloxacin
  • nicardipine
  • pentamidine
  • phenytoin
  • prochlorperazine
  • promethazine
  • topotecan
  • vancomycin
  • verapamil
  • vinorelbine
.
• Topical: Consult health care professional before administering topical preparations to determine which skin preparation regimen should be followed. Avoid tight occlusive dressings because of irritation to surrounding healthy tissue. A loose gauze dressing for cosmetic purposes is usually preferred. Wear gloves when applying medication. Do not use metallic applicator.

• Explain purpose of fluorouracil to patient.
• Instruct patient to notify health care professional if fever; chills; sore throat; signs of infection; yellowing of skin or eyes; abdominal pain; joint or flank pain; swelling of feet or legs; bleeding gums; bruising; petechiae; or blood in urine, stool, or emesis occurs. Caution patient to avoid crowds and persons with known infections. Instruct patient to use soft toothbrush and electric razor. Patients should be cautioned not to drink alcoholic beverages or take products containing aspirin or NSAIDs.
  • Advise patient to rinse mouth with clear water after eating and drinking and to avoid flossing to minimize stomatitis. Viscous lidocaine may be used if mouth pain interferes with eating. Stomatitis pain may require treatment with opioid analgesics.
  • Discuss with patient the possibility of hair loss. Explore methods of coping.
  • Caution patient to use sunscreen and protective clothing to prevent phototoxicity reactions.
  • Instruct patient not to receive any vaccinations without advice of health care professional.
  • Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications. Increase dietary intake of thiamine may be recommended.
  • Rep: May cause fetal harm. Advise females of reproductive potential and male patients with female partners of reproductive potential to use effective contraception during therapy and for at least 3 mo following completion of therapy and to avoid breastfeeding during therapy. Inform patients that fertility may be impaired during therapy.
  • Emphasize the importance of routine follow-up lab tests to monitor progress and to check for side effects.
• Topical: Instruct patient in correct application of solution or cream. Emphasize importance of avoiding the eyes; caution should also be used when applying medication near mouth and nose. If patient uses clean finger to self-administer, emphasize importance of washing hands thoroughly after application. Explain that erythema, scaling, and blistering with pruritus and burning sensation are expected. Advise patient to avoid sunlight or ultraviolet light (tanning booths) as much as possible; may increase side effects. Therapy is discontinued when erosion, ulceration, and necrosis occur in 2–6 wk (10–12 wk for basal cell carcinomas). Skin heals 4–8 wk later.
  • Fluorouracil may be fatal if ingested by pets. Do not allow pets to be in contact with the container or the skin where fluorouracil topical has been applied. Store out of reach of pets. Safely discard or clean any cloth or applicator that may retain fluorouracil and avoid leaving any residues on your hands, clothing, carpeting or furniture.

• Tumor regression.
• Removal of solar keratoses or superficial basal cell skin cancers.

Carac, Efudex, Tolak

NDC Code^*

• 0187- Bausch Health US LLC
  • 0187-3204- Efudex
    • 0187-3204-47- 1 TUBE in 1 CARTON (0187-3204-47) > 40 g in 1 TUBE

• 0187- Bausch Health Americas, Inc.
  • 0187-5200- Carac
    • 0187-5200-30- 1 TUBE in 1 CARTON (0187-5200-30) > 30 g in 1 TUBE

• 0378- Mylan Pharmaceuticals Inc.
  • 0378-4791- Fluorouracil
    • 0378-4791-06- 1 TUBE in 1 CARTON (0378-4791-06) > 40 g in 1 TUBE

• 0703- Teva Parenteral Medicines, Inc.
  • 0703-3015- Adrucil
    • 0703-3015-13- 10 VIAL, SINGLE-DOSE in 1 CARTON (0703-3015-13) > 10 mL in 1 VIAL, SINGLE-DOSE (0703-3015-11)

• 0703- Teva Parenteral Medicines, Inc.
  • 0703-3018- Adrucil
    • 0703-3018-12- 5 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (0703-3018-12) > 50 mL in 1 VIAL, PHARMACY BULK PACKAGE (0703-3018-11)

• 0703- Teva Parenteral Medicines, Inc.
  • 0703-3019- Adrucil
    • 0703-3019-12- 5 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (0703-3019-12) > 100 mL in 1 VIAL, PHARMACY BULK PACKAGE (0703-3019-11)

• 16110- Almirall, LLC
  • 16110-812- Fluoroplex
    • 16110-812-30- 1 TUBE in 1 CARTON (16110-812-30) > 30 g in 1 TUBE

• 16729- Accord Healthcare, Inc.
  • 16729-276- Fluorouracil
    • 16729-276-67- 10 VIAL in 1 CARTON (16729-276-67) > 20 mL in 1 VIAL (16729-276-05)

• 16729- Accord Healthcare, Inc.
  • 16729-276- Fluorouracil
    • 16729-276-68- 10 VIAL in 1 CARTON (16729-276-68) > 10 mL in 1 VIAL (16729-276-03)

• 16729- Accord Healthcare, Inc.
  • 16729-276- Fluorouracil
    • 16729-276-11- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (16729-276-11) > 50 mL in 1 VIAL, PHARMACY BULK PACKAGE

• 16729- Accord Healthcare, Inc.
  • 16729-276- Fluorouracil
    • 16729-276-38- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (16729-276-38) > 100 mL in 1 VIAL, PHARMACY BULK PACKAGE

• 25021- Sagent Pharmaceuticals
  • 25021-215- fluorouracil
    • 25021-215-98- 1 BOTTLE in 1 CARTON (25021-215-98) > 50 mL in 1 BOTTLE

• 25021- Sagent Pharmaceuticals
  • 25021-215- fluorouracil
    • 25021-215-99- 1 BOTTLE in 1 CARTON (25021-215-99) > 100 mL in 1 BOTTLE

• 28105- HILL DERMACEUTICALS, INC.
  • 28105-421- TOLAK
    • 28105-421-40- 1 TUBE in 1 CARTON (28105-421-40) > 40 g in 1 TUBE

• 50090- A-S Medication Solutions
  • 50090-4264- Fluorouracil
    • 50090-4264-0- 1 TUBE in 1 CARTON (50090-4264-0) > 40 g in 1 TUBE

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4062- Fluorouracil
    • 51672-4062-1- 1 BOTTLE in 1 CARTON (51672-4062-1) > 10 mL in 1 BOTTLE

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4063- Fluorouracil
    • 51672-4063-1- 1 BOTTLE in 1 CARTON (51672-4063-1) > 10 mL in 1 BOTTLE

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4118- Fluorouracil
    • 51672-4118-2- 1 TUBE in 1 CARTON (51672-4118-2) > 25 g in 1 TUBE

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4118- Fluorouracil
    • 51672-4118-5- 5 g in 1 TUBE (51672-4118-5)

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4118- Fluorouracil
    • 51672-4118-6- 1 TUBE in 1 CARTON (51672-4118-6) > 40 g in 1 TUBE

• 51862- Mayne Pharma Inc.
  • 51862-362- FLUOROURACIL
    • 51862-362-40- 1 TUBE in 1 CARTON (51862-362-40) > 40 g in 1 TUBE

• 63323- Fresenius Kabi USA, LLC
  • 63323-117- Fluorouracil
    • 63323-117-59- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (63323-117-59) > 50 mL in 1 VIAL, PHARMACY BULK PACKAGE

• 63323- Fresenius Kabi USA, LLC
  • 63323-117- Fluorouracil
    • 63323-117-69- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (63323-117-69) > 100 mL in 1 VIAL, PHARMACY BULK PACKAGE

• 63323- Fresenius Kabi USA, LLC
  • 63323-117- Fluorouracil
    • 63323-117-18- 10 VIAL, SINGLE-DOSE in 1 TRAY (63323-117-18) > 10 mL in 1 VIAL, SINGLE-DOSE

• 63323- Fresenius Kabi USA, LLC
  • 63323-117- Fluorouracil
    • 63323-117-28- 10 VIAL, SINGLE-DOSE in 1 TRAY (63323-117-28) > 20 mL in 1 VIAL, SINGLE-DOSE

• 63323- Fresenius Kabi USA, LLC
  • 63323-117- Fluorouracil
    • 63323-117-19- 10 VIAL, SINGLE-DOSE in 1 TRAY (63323-117-19) > 10 mL in 1 VIAL, SINGLE-DOSE

• 63323- Fresenius Kabi USA, LLC
  • 63323-117- Fluorouracil
    • 63323-117-10- 10 VIAL, SINGLE-DOSE in 1 TRAY (63323-117-10) > 10 mL in 1 VIAL, SINGLE-DOSE

• 63323- Fresenius Kabi USA, LLC
  • 63323-117- Fluorouracil
    • 63323-117-20- 10 VIAL, SINGLE-DOSE in 1 TRAY (63323-117-20) > 20 mL in 1 VIAL, SINGLE-DOSE

• 63323- Fresenius Kabi USA, LLC
  • 63323-117- Fluorouracil
    • 63323-117-51- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (63323-117-51) > 50 mL in 1 VIAL, PHARMACY BULK PACKAGE

• 63323- Fresenius Kabi USA, LLC
  • 63323-117- Fluorouracil
    • 63323-117-61- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (63323-117-61) > 100 mL in 1 VIAL, PHARMACY BULK PACKAGE

• 63323- Fresenius Kabi USA, LLC
  • 63323-117- Fluorouracil
    • 63323-117-58- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (63323-117-58) > 50 mL in 1 VIAL, PHARMACY BULK PACKAGE

• 63323- Fresenius Kabi USA, LLC
  • 63323-117- Fluorouracil
    • 63323-117-68- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (63323-117-68) > 100 mL in 1 VIAL, PHARMACY BULK PACKAGE

• 64370- Pierre Fabre Pharmaceuticals, Inc.
  • 64370-421- TOLAK
    • 64370-421-40- 1 TUBE in 1 CARTON (64370-421-40) > 40 g in 1 TUBE

• 64370- Pierre Fabre Pharmaceuticals, Inc.
  • 64370-421- TOLAK
    • 64370-421-83- 8 CARTON in 1 CARTON (64370-421-83) > 1 TUBE in 1 CARTON > 3.5 g in 1 TUBE (64370-421-03)

• 66530- Spear Dermatology Products
  • 66530-249- FLUOROURACIL
    • 66530-249-40- 40 g in 1 TUBE (66530-249-40)

• 66530- Spear Dermatology Products Inc
  • 66530-258- Fluorouracil
    • 66530-258-30- 30 g in 1 TUBE (66530-258-30)

• 68001- BluePoint Laboratories
  • 68001-266- Fluorouracil
    • 68001-266-27- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (68001-266-27) > 50 mL in 1 VIAL, PHARMACY BULK PACKAGE (68001-266-24)

• 68001- BluePoint Laboratories
  • 68001-266- Fluorouracil
    • 68001-266-32- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (68001-266-32) > 100 mL in 1 VIAL, PHARMACY BULK PACKAGE (68001-266-33)

• 68001- BluePoint Laboratories
  • 68001-266- Fluorouracil
    • 68001-266-30- 10 VIAL in 1 CARTON (68001-266-30) > 10 mL in 1 VIAL (68001-266-28)

• 68001- BluePoint Laboratories
  • 68001-266- Fluorouracil
    • 68001-266-31- 10 VIAL in 1 CARTON (68001-266-31) > 20 mL in 1 VIAL (68001-266-29)

• 68083- Gland Pharma Limited
  • 68083-269- Fluorouracil
    • 68083-269-10- 10 VIAL in 1 CARTON (68083-269-10) > 10 mL in 1 VIAL (68083-269-01)

• 68083- Gland Pharma Limited
  • 68083-270- Fluorouracil
    • 68083-270-10- 10 VIAL in 1 CARTON (68083-270-10) > 20 mL in 1 VIAL (68083-270-01)

• 68083- Gland Pharma Limited
  • 68083-292- Fluorouracil
    • 68083-292-01- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (68083-292-01) > 50 mL in 1 VIAL, PHARMACY BULK PACKAGE

• 68083- Gland Pharma Limited
  • 68083-293- Fluorouracil
    • 68083-293-01- 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (68083-293-01) > 100 mL in 1 VIAL, PHARMACY BULK PACKAGE