section name header

Pronunciation ⬇

MEK-li-zeen audio

Classifications ⬆ ⬇

Therapeutic Classification: antiemetics, antihistamines

Indications ⬆ ⬇

BEERS REMS

Action ⬆ ⬇

Therapeutic Effects:

Pharmacokinetics ⬆ ⬇

Absorption: Absorbed after oral administration.

Distribution: Unknown.

Metabolism/Excretion: Primarily metabolized by liver via the CYP2D6 isoenzyme; the CYP2D6 isoenzyme exhibits genetic polymorphism (7% of population may be poor metabolizers and may have significantly ↑ meclizine concentrations and an ↑ risk of adverse effects).

Half-life: 6 hr.

Time/Action Profile ⬆ ⬇

(antihistaminic effects)

ROUTEONSETPEAKDURATION
PO1 hrunknown8–24 hr

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

EENT: blurred vision.

GI: dry mouth.

Neuro: drowsiness, fatigue.

Interactions ⬆ ⬇

Drug-Drug:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Antivert, Bonine

Code ⬆

NDC Code*