section name header

Pronunciation

ir-be-SAR-tan audio

Classifications

Therapeutic Classification: antihypertensives

Pharmacologic Classification: angiotensin II receptor antagonists

Indications

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: 60–80% absorbed following oral administration.

Distribution: Crosses the placenta.

Protein Binding: 90%.

Metabolism/Excretion: Some hepatic metabolism; 20% excreted in urine, 80% in feces.

Half-life: 11–15 hr.

Time/Action Profile

(antihypertensive effect with chronic dosing)

ROUTEONSETPEAKDURATION
POwithin 2 hr2 wks24 hr

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: chest pain, edema, hypotension, tachycardia.

Derm: rash.

F and E: hyperkalemia.

GI: abdominal pain, diarrhea, dyspepsia, nausea, vomiting.

GU: impaired renal function.

MS: pain.

Neuro: anxiety, dizziness, fatigue, headache.

Misc: ANGIOEDEMA.

Interactions

Drug-Drug:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Avapro

Code

NDC Code*