section name header

Pronunciation

a-PIX-a-ban audio

Classifications

Therapeutic Classification: anticoagulants

Pharmacologic Classification:

Indications

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: 50% absorbed following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Primarily metabolized by the liver by the CYP3A4 isoenzyme; excreted in urine and feces. Biliary and direct intestinal excretion account for fecal elimination.

Half-life: 6 hr (12 hr after repeated dosing due to prolonged absorption).

Time/Action Profile

(effect on hemostasis)

ROUTEONSETPEAKDURATION
POunknown3–4 hr†24 hr

†Blood levels.

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Hemat: bleeding.

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS) .

Interactions

Drug-Drug:

Drug-Natural Products:

Route/Dosage

Reduction in Risk of Stroke/Systemic Embolism in Nonvalvular Atrial Fibrillation

Renal Impairment

Prevention of Deep Vein Thrombosis Following Knee or Hip Replacement Surgery

Treatment of Deep Vein Thrombosis or Pulmonary Embolism

Reduction in Risk of Recurrence of Deep Vein Thrombosis or Pulmonary Embolism

Availability

(Generic available)

Assessment

Toxicity and Overdose:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Eliquis

Code

NDC Code*