fur-OH-se-mide 
Absorption: 60–67% absorbed after oral administration (↓ in acute HF and in renal failure); also absorbed from IM sites; IV administration results in complete availability; 99.6% absorbed after subcut administration.
Distribution: Crosses placenta, enters breast milk.
Protein Binding: 91–99%.
Metabolism/Excretion: Minimally metabolized by liver, some nonhepatic metabolism, some renal excretion as unchanged drug.
Half-life: 30–120 min (↑ in renal impairment).
(diuretic effect)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | 30–60 min | 1–2 hr | 6–8 hr |
| IM | 10–30 min | unknown | 4–8 hr |
| IV | 5 min | 30 min | 2 hr |
| Subcut | unknown | unknown | 8 hr |
Contraindicated in:
Use Cautiously in:
CV: hypotension.
Derm: ERYTHEMA MULTIFORME, photosensitivity, pruritus, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, urticaria.
EENT: hearing loss, tinnitus.
Endo: hypercholesterolemia, hyperglycemia, hypertriglyceridemia, hyperuricemia.
F and E: dehydration, hypocalcemia, hypochloremia, hypokalemia, hypomagnesemia, hyponatremia, hypovolemia, metabolic alkalosis.
GI: ↑ liver enzymes, anorexia, constipation, diarrhea, dry mouth, dyspepsia, nausea, pancreatitis, vomiting.
GU: ↑ BUN, excessive urination, nephrocalcinosis.
Hemat: AGRANULOCYTOSIS, APLASTIC ANEMIA, hemolytic anemia, leukopenia, thrombocytopenia.
MS: muscle cramps.
Neuro: blurred vision, dizziness, headache, paresthesia, vertigo.
Misc: fever.
Drug-Drug:
Edema
Hypertension
(Generic available)
IV Administration:
NDC Code*
