section name header

Pronunciation

TORE-em-i-feen audio

Classifications

Therapeutic Classification: antineoplastics

Pharmacologic Classification: antiestrogens

Indications

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Well absorbed following oral administration.

Distribution: Widely distributed; 99% bound to plasma proteins.

Protein Binding: 99.5%.

Metabolism/Excretion: Extensively metabolized; undergoes enterohepatic circulation.

Half-life: 5 days.

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
POunknown3 hr4–6 wk

†Steady-state blood levels occur after 4–6 wk.

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CNS: depression, dizziness, headache, lethargy.

EENT: blurred vision, cataracts, corneal keratopathy, dry eyes, glaucoma.

CV: HF, MI, PULMONARY EMBOLISM, TORSADE DE POINTES, angina, arrhythmias, edema, QTc interval prolongation, thrombophlebitis.

GI: HEPATOTOXICITY, nausea, vomiting.

GU: ENDOMETRIAL CANCER, vaginal discharge, endometrial hyperplasia/hypertrophy, uterine polyps, vaginal bleeding.

Derm: sweating.

F and E: hypercalcemia.

Hemat: anemia.

Misc: hot flashes, tumor flare.

Interactions

Drug-Drug:

Drug-Natural Products:

Route/Dosage

Availability

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Fareston

Pot. Nursing Diagnoses

Code

NDC Code*