a-mox-i-SILL-in 
Therapeutic Classification: anti-infectives, antiulcer agents
Pharmacologic Classification: aminopenicillins
Unlabeled Use:
Spectrum:
Absorption: Well absorbed from duodenum (75–90%). More resistant to acid inactivation than other penicillins.
Distribution: Diffuses readily into most body tissues and fluids. CSF penetration increased when meninges are inflamed. Crosses placenta; enters breast milk in small amounts.
Metabolism/Excretion: 70% excreted unchanged in the urine; 30% metabolized by the liver.
Half-life: Neonates: 3.7 hr; Infants and Children: 1–2 hr; Adults: 0.7–1.4 hr.
Contraindicated in:
Use Cautiously in:
Derm: rash, ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, urticaria.
GI: diarrhea, ↑ liver enzymes, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), nausea, vomiting.
Hemat: blood dyscrasias.
Neuro: SEIZURES (HIGH DOSES).
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), SERUM SICKNESS, superinfection.
Drug-Drug:
Most Infections
Renal Impairment
Helicobacter pylori
Endocarditis Prophylaxis
(Generic available)
NDC Code*
