Opioid-Induced Constipation in Patients with Advanced Illness

• SC (Adults >114 kg): 0.15 mg/kg every other day, as needed (not to exceed 1 dose every 24 hr).

Renal Impairment

• (Adults ): CCr <60 mL/min: use 50% of recommended dose based on weight.
• SC (Adults 62–114 kg): 12 mg every other day, as needed (not to exceed 1 dose every 24 hr).
• SC (Adults 38–62 kg): 8 mg every other day, as needed (not to exceed 1 dose every 24 hr).
• SC (Adults <38 kg): 0.15 mg/kg every other day, as needed (not to exceed 1 dose every 24 hr).

Renal Impairment

• SC (Adults >114 kg): CCr <60 mL/min: 0.075 mg/kg every other day, as needed (not to exceed 1 dose every 24 hr).

Renal Impairment

• SC (Adults 62–114 kg): CCr <60 mL/min: 6 mg every other day, as needed (not to exceed 1 dose every 24 hr).

Renal Impairment

• SC (Adults 38–<62 kg): CCr <60 mL/min: 4 mg every other day, as needed (not to exceed 1 dose every 24 hr).

Renal Impairment

• SC (Adults <38 kg): CCr <60 mL/min: 0.15 mg/kg every other day, as needed (not to exceed 1 dose every 24 hr).

Opioid-Induced Constipation in Patients with Non-Cancer Pain

• SC (Adults ): 12 mg once daily.
• PO (Adults ): 450 mg once daily.

Renal Impairment

• SC (Adults ): CCr <60 mL/min: 6 mg once daily.

Renal Impairment

• PO (Adults ): CCr <60 mL/min: 150 mg once daily.

Hepatic Impairment

• SC (Adults >114 kg): Severe hepatic impairment: 0.075 mg/kg once daily.

Hepatic Impairment

• SC (Adults 62–114 kg): Severe hepatic impairment: 6 mg once daily.

Hepatic Impairment

• SC (Adults 38–<62 kg): Severe hepatic impairment: 4 mg once daily.

Hepatic Impairment

• SC (Adults <38 kg): Severe hepatic impairment: 0.075 mg/kg once daily.

Hepatic Impairment

• PO (Adults ): Moderate or severe hepatic impairment: 150 mg once daily.