Therapeutic Classification: antidepressants
Pharmacologic Classification: selective serotonin and norepinephrine reuptake inhibitors-SSNRIs
BEERS REMS
Absorption: Well absorbed following oral administration.
Distribution: Unknown.
Protein Binding: >90%.
Half-Life: 12 hr.
Contraindicated in:
Use Cautiously in:
CV: hypertension, orthostatic hypotension
Derm: ↑sweating, ERYTHEMA MULTIFORME, pruritus, rash, STEVENS-JOHNSON SYNDROME (SJS)
EENT: ↑intraocular pressure, blurred vision
Endo: SIADH
F and E: hyponatremia
GI: ↓appetite, constipation, dry mouth, nausea, ↑liver enzymes, diarrhea, gastritis, HEPATOTOXICITY, PANCREATITIS, vomiting
GU: dysuria, ↓libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction, urinary retention
Hemat: BLEEDING
Neuro: drowsiness, fatigue, insomnia, activation of mania, dizziness, fainting, falls, NEUROLEPTIC MALIGNANT SYNDROME, nightmares, SEIZURES, SUICIDAL THOUGHTS, tremor
Misc: SEROTONIN SYNDROME
Drug-drug:
Drug-Natural Products:
Major Depressive Disorder
Generalized Anxiety Disorder
Diabetic Peripheral Neuropathic Pain
Fibromyalgia
Chronic Musculoskeletal Pain
Lab Test Considerations:
NDC Code