section name header

Pronunciation ⬇

PRI-mi-done

Classifications ⬆ ⬇

Therapeutic Classification: anticonvulsants

Indications ⬆ ⬇

BEERS REMS

Unlabeled Use:

Action ⬆ ⬇

Therapeutic Effects:

Pharmacokinetics ⬆ ⬇

Absorption: 80–100% absorbed from the GI tract when administered orally.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Converted to phenobarbital and another active anticonvulsant compound by the liver.

Half-life: 3–7 hr.

Time/Action Profile ⬆ ⬇

(anticonvulsant effect)

ROUTEONSETPEAKDURATION
PO4–7 days7–10 days8–12 hr

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: edema, orthostatic hypotension.

Derm: alopecia, rash.

EENT: visual changes.

GI: anorexia, hepatitis, nausea, vomiting.

Hemat: blood dyscrasias, folic acid deficiency, megaloblastic anemia.

Neuro: ataxia, drowsiness, vertigo, excitement (↑ in children), SUICIDAL THOUGHTS.

Resp: dyspnea.

Interactions ⬆ ⬇

Drug-Drug:

Drug-Natural Products:

Drug-Food:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations: Toxicity and Overdose:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Mysoline

Code ⬆

NDC Code*