Therapeutic Classification: antipsychotics, mood stabilizers
Pharmacologic Classification: thienobenzodiazepines
BEERS REMS
Absorption: Well absorbed but rapidly metabolized by first-pass effect, resulting in 60% bioavailability. Conventional tablets and orally disintegrating tablets (Zydis) are bioequivalent. IM administration results in significantly higher blood levels (5 times that of oral).
Distribution: Extensively distributed.
Protein Binding: 93%.
Half-Life: 2154 hr.
(antipsychotic effects)
ROUTE | ONSET | PEAK* | DURATION |
---|---|---|---|
PO | unknown | 6 hr | unknown |
IM | rapid | 1545 min | 24 hr |
*Blood levels.
Contraindicated in:
Use Cautiously in:
CV: orthostatic hypotension, bradycardia, chest pain, syncope, tachycardia
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), photosensitivity
EENT: amblyopia, rhinitis, ↑salivation, pharyngitis
Endo: galactorrhea, goiter, gynecomastia, hyperglycemia, hyperprolactinemia
F and E: ↑thirst
GI: ↑liver enzymes, constipation, dry mouth, weight loss, abdominal pain, dysphagia, nausea
GU: ↓fertility (females), ↓libido, amenorrhea, impotence, urinary incontinence
Hemat: AGRANULOCYTOSIS, leukopenia, neutropenia
MS: hypertonia, joint pain
Neuro: agitation, delirium, dizziness, headache, restlessness, sedation, tremor, weakness, dystonia, falls, insomnia, mood changes, NEUROLEPTIC MALIGNANT SYNDROME, personality disorder, SEIZURES, speech impairment, SUICIDAL THOUGHTS, tardive dyskinesia
Resp: aspiration, cough, dyspnea
Misc: body temperature dysregulation, fever, flu-like syndrome
Drug-drug:
Schizophrenia
Acute Manic or Mixed Episodes Associated With Bipolar I Disorder
Maintenance Treatment of Bipolar I Disorder
Acute Agitation due to Schizophrenia or Bipolar I Mania
Depressive Episodes Associated With Bipolar I Disorder
Treatment-Resistant Depression
Lab Test Considerations:
Zyprexa Relprevv is only prescribed through the Zyprexa Relprevv Patient Care Program. Prescribers, pharmacies, and patients must be educated about the program and must comply with the program requirements.
Advise patient to take medication as directed and not to skip doses or double up on missed doses. May need to discontinue gradually. Advise patient to read the Medication Guide prior to starting therapy and with each Rx refill in case of changes. Explain the Zyprexa Relprevv Patient Care Program to patient and encourage patient to enroll in the Zyprexa Relprevv Patient Care Program registry.
NDC Code