section name header

Pronunciation ⬇

a-TEN-oh-lole

Classifications ⬆ ⬇

Therapeutic Classification: antianginals, antihypertensives

Pharmacologic Classification: beta blockers

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • Blocks stimulation of beta1(myocardial)-adrenergic receptors. Does not usually affect beta2(pulmonary, vascular, uterine)-receptor sites.
Therapeutic effects:
  • Decreased BP and heart rate.
  • Decreased frequency of attacks of angina pectoris.
  • Reduction of cardiovascular mortality associated with MI.

Pharmacokinetics ⬆ ⬇

Absorption: 50–60% absorbed after oral administration.

Distribution: Minimal penetration of CNS.

Metabolism/Excretion: 40–50% excreted unchanged by the kidneys; remainder excreted in feces as unabsorbed drug.

Half-Life: 6–9 hr.

Time/Action Profile ⬆ ⬇

(cardiovascular effects)

ROUTEONSETPEAKDURATION
PO1 hr2–4 hr24 hr



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: BRADYCARDIA, HF, hypotension, peripheral vasoconstriction

Derm: rash

EENT: blurred vision, stuffy nose

Endo: hyperglycemia, hypoglycemia

GI: ↑liver enzymes, constipation, diarrhea, nausea, vomiting

GU: erectile dysfunction, ↓libido, urinary frequency

MS: arthralgia, back pain, joint pain

Neuro: fatigue, weakness, anxiety, depression, dizziness, drowsiness, insomnia, memory loss, mental status changes, nervousness, nightmares

Resp: bronchospasm, PULMONARY EDEMA, wheezing

Misc: drug-induced lupus syndrome

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Renal Impairment

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Toxicity and Overdose:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Tenormin

Pill Image

atenolol_195-8899.jpg

Code ⬆

NDC Code