section name header

Pronunciation

val-SAR-tan

Classifications

Therapeutic Classification: antihypertensives

Pharmacologic Classification: angiotensin II receptor antagonists

Indications

REMS


Action

  • Blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II at various receptor sites, including vascular smooth muscle and the adrenal glands.
Therapeutic effects:
  • Lowering of BP in patients with hypertension.
  • Decreased risk of HF-related hospitalizations in patients with heart failure.
  • Decreased risk of death from cardiovascular causes in patients with left ventricular systolic dysfunction following myocardial infarction.

Pharmacokinetics

Absorption: 10–35% absorbed following oral administration.

Distribution: Crosses the placenta.

Protein Binding: 95%.

Metabolism/Excretion: Minor metabolism by the liver; 13% excreted in urine; 83% in feces.

Half-Life: 6 hr.

Time/Action Profile

(antihypertensive effect)

ROUTEONSETPEAKDURATION
POwithin 2 hr*4 wks24 hr



*After single dose.

Chronic dosing.

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: edema, hypotension

EENT: pharyngitis, rhinitis, sinusitis

F and E: hyperkalemia

GI: abdominal pain, diarrhea, nausea

GU: impaired renal function

MS: arthralgia, back pain

Neuro: dizziness, fatigue, headache

Misc: ANGIOEDEMA

Interactions

Drug-drug:

Route/Dosage

Hypertension

Heart Failure

Post-Myocardial Infarction

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Diovan

Pot. Nursing Diagnoses

Code

NDC Code